Results 111 to 120 of about 19,981,156 (315)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Innovative Learning Using E-Modules

open access: yesJETISH: Journal of Education Technology Information Social Sciences and Health
This research discusses the innovative use of e-modules in learning and the challenges in creating or developing creative and innovative e-modules. Education in the current digital era is undergoing a significant revolution with the adoption of technology as the main catalyst for change.
Mahardika Ardi Manggala   +2 more
openaire   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

The Impact of Patient-Centric Interactive E-Module in Pathology Among Medical Undergraduates. [PDF]

open access: yesMed Sci Educ, 2023
Venkatesan J   +4 more
europepmc   +1 more source

Penggunaan modul pembelajaran elektronik (MPE) pengenalan pelancongan H 111 : tinjauan terhadap pensyarah dan pelajar Diploma Pengurusan Pelancongan, Politeknik Johor Bahru [PDF]

open access: yes, 2003
Era Teknologi Maklumat dan Komunikasi (ICT) telah melihat perkembangan penggunaan komputer sebagai alat berpotensi untuk meningkatkan proses pengajaran dan pembelajaran.
Mohamad, Harulnizam
core  

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Successful integration of thyroid cytopathology and surgical pathology education in an E-module format. [PDF]

open access: yesJ Pathol Inform, 2022
Rohr JM   +5 more
europepmc   +1 more source

Point and interval estimates of abundance using multiple covariate distance sampling: an example using great bustards. [PDF]

open access: yes, 2009
Previously in the University eprints HAIRST pilot service at http://eprints.st-andrews.ac.uk/archive/00000447/The pdf file contains the tech report, the ASCII (.R) file contains the accompanying R code.Description of computations to produce sex-specific ...
Rexstad, Eric
core  

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