Results 121 to 130 of about 21,181,337 (333)

Communication Technologies of Crowdsourcing in Contemporary Global and Russian Public Policy

Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2018
Introduction. The paper studies crowdsourcing technologies of public communication that is an essential part of the global and regional contemporary political spaces as a method of nonviolent conflict resolution and reduction of social tensions in ...
Liliya S. Pankratova, Svetlana V. Shakarbieva   +1 more
doaj   +1 more source

The Development of an E-Participation Platform for Rural Areas in the Study Area of Niedernhall [PDF]

, 2019
The participation methods changed in recent years with the evolution of communication methods in general. It goes from an analog approach to a more information technology-based concept.
Coors, Volker, Santhanavanich, Thunyathep, Würstle, Patrick   +2 more
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Playing (with) Democracy: A Review of Gamified Participation Approaches

, 2016
Albeit a wide range of e-participation platforms being already available, the level of public participation remains low. Governments around the world as well as academia are currently exploring new ways to design participation methods that are more ...
Sarah-Kristin Thiel, Michaela R. Reisinger, K. Röderer, Peter Fröhlich   +3 more
semanticscholar   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Epistemology of e-democracy and e-governance through scientific mapping

Tourism & Management Studies
This paper aims to address the current limitations in knowledge about e-democracy by establishing the conceptual, intellectual, and social structure of scientific literature.
Esther García-Río , Pedro Baena-Luna
doaj  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

E-participation in portuguese local governments : an exploratory research about emerging networks [PDF]

, 2007
In this paper, we analyse the appearance of new forms of electronic participation in Portuguese local communities. Using some cases studies of e-participation in municipalities, we sustain a main argument: technical modernization doesn’t automatically ...
Coelho, Zara Pinto, Neves, José Pinheiro   +1 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source