Results 131 to 140 of about 21,181,337 (333)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Role of Administrative Digitalization and Economic Development in Shaping Fiscal Efficiency: A Cross-National Analysis [PDF]

open access: yesOvidius University Annals: Economic Sciences Series
The paper investigates the relationship between government digitalization and economic and fiscal performance in European countries. Two multiple regressions were used with GDP(Gross Domestic Product) per capita and Tax Revenue as Percentage of GDP ...
Lăcrămioara Mansour   +2 more
doaj  

Content Analysis of E-Participation Platforms in Taiwan with Topic Modeling: How to Train and Evaluate Neural Topic Models?

open access: yesApplied Sciences
E-participation platforms, such as iVoting and Join in Taiwan, provide digital spaces for citizens to engage in deliberation, voting, and oversight.
Moritz Sontheimer   +3 more
doaj   +1 more source

Barriers to Socio-economic Opportunities in Africa: An e-Government Perspective [PDF]

open access: yes, 2009
Various barriers to socio-economic opportunities in Africa are explored though e-Government as a lens of study. Using grounded theory methodology, scholarly literature on e-Government in Africa has been analyzed to model various barriers. The research
Demissie, Dawit H.   +1 more
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Centralization of the System of E-Participation in the Russian Federation: Expert Interviews Data

open access: yesУправленческое консультирование
This article presents the results of the study aimed at analyzing the institutional transformations of the E-Participation system in Russia. Since 2020, the e-participation system in Russia has undergone significant transformations associated with the ...
G. O. Panfilov, A. V. Chugunov
doaj   +1 more source

Online participation: the Woodberry Down experiment [PDF]

open access: yes, 2002
The internet and world wide web are generating radical changes in the way we are able tocommunicate. Our ability to engage communities and individuals in designing theirenvironment is also beginning to change as new digital media provide ways in ...
Batty, M   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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