Results 101 to 110 of about 882,596 (264)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Inequality Adjustment Criteria for the Human Development Index [PDF]
Our goal is to analyse the inequality aspects of Human Development Index and to propose a new aggregation function that can adjust it by considering inequality penalisation.
Enrico Casadio Tarabusi, Giulio Guarini
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Shaping up e-Participation Evaluation: A Multi-criteria Analysis
, 2018 E-Participation is the use of internet-based technology to empower and include citizens in government decision making processes. The United Nations has evaluated e-Participation around the globe on a regular basis. This evaluation has been criticized for
Leif Sundberg +2 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Effects of WIC Program Participation on Food Consumption and Diet Quality
This paper examines the effect of WIC program Participation on food consumption and diet quality of U.S. children between 2 and 4 years of age. Diet quality is assessed using the Healthy Eating Index, U.S.
Chandran, Ram
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
REGIONAL DATA AND KNOWLEDGE MANAGEMENT FOR THE DESIGN OF NEW E-GOVERNMENT SERVICES [PDF]
The paper introduces an innovative approach related to the sustainable regional strategy design and implementation, suggesting the process re-engineering according to the new knowledge management and citizen-oriented governance paradigm.
Mihaela MUREªAN
core
Youth participation and health promotion: strategy for human development
, 2011 A participação juvenil tem sido investigada em vários campos do conhecimento. Embora a literatura aborde aspectos relativos às dimensões psicológica, educacional e cívica, a tendência não tem sido a de relacioná-las à perspectiva da saúde.
Lima, Isabel Maria Sampaio Oliveira +1 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source