Results 101 to 110 of about 33,283,713 (295)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
E-Book Readers in Higher Education
SAGE Open, 2013 This article reports on a research project at the University of Agder that has studied the use of e-readers as a tool for academic study. E-readers (Kindle DX and iPad) were loaded with texts from required reading lists in five courses with 94 ...
Arthur N. Olsen +2 more
doaj +1 more source
PROTOTIPE SMART CARD READER E-KTP DENGAN PROGRAM VISUAL BASIC [PDF]
, 2014 PROTOTYPE SMART CARD READER WITH PROGRAM VISUAL BASIC (2014 : xv + 60pages + 32pictures + 9appendixs) CITRA AGUSTIN PUTRI TAMA 0611 3033 0243 ELEKTRICAL ENGINEERING DEPARTMENT PROGRAM STUDY OF TELECOMUNICATION ENGINERRING POLITECHNIC OF SRIWIJAYA
TESISIA, PRASTIKA, AGUSTIN P.T, CITRA
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Analysis of Cattle Foot Lesions Recorded at Trimming in the Southwest of England
AnimalsBackground: The UK has a high incidence of lameness in cattle, which is costly in terms of economics and welfare. Most causes of bovine lameness originate in the foot but there are several different conditions causing lameness.
Nick Britten +4 more
doaj +1 more source
ANALISIS DAN PERANCANGAN E-BOOK READER BERBASIS WEB MENGGUNAKAN PHP DAN FLEX PADA PT. MITRA INFOTEK PRATAMA [PDF]
, 2010 ANALISIS DAN PERANCANGAN E-BOOK READER BERBASIS WEB MENGGUNAKAN PHP DAN FLEX PADA PT.
PRADIPTA, ALVIN +2 more
core
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source