Results 151 to 160 of about 714,481 (251)

Crosslinked hyaluronic acid-doped polypyrrole: Stable, nonbiofouling implantable bioelectrodes for in vivo signal recording. [PDF]

Mater Today Bio
Yi J, Kim G, Lee S, Lee JY.
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

The UK e-Science Programme and the Grid

, 2002
This paper describes the £120M UK ‘e-Science’ initiative and begins by defining what is meant by the term e-Science. The majority of the £120M, some £85M, is funding large-scale e-Science pilot projects in many areas of science and engineering.
Hey, Tony, Hey, A J G, Trefethen, Anne, Trefethen, A E   +3 more
core  

Tunable low-rate genomic recombination with Cre-<i>lox</i> in <i>Escherichia coli</i>: a versatile tool for anoxic environmental biosensing and synthetic biology. [PDF]

Appl Environ Microbiol
Garabello E, Yoon H, Reid MC, Giometto A.   +3 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Quantum cryptanalysis of ultralightweight mutual authentication protocols: A Grover's search model. [PDF]

PLoS One
Shahzadi M, Khalid M, Qadir S, Hussain M, Mujahid U, Najam-Ul-Islam M.   +5 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Editorial: Chromatin modifications and gene expression: from mechanisms to therapeutic implications in disease. [PDF]

Front Genet
Burlibasa L, Nassa G, Botezatu A, Salvati A.   +3 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

A high-toughness, rare-earth-free magnesium alloy with excellent biocompatibility profile: Integrated in vitro and in vivo characterization. [PDF]

Mater Today Bio
Weber L, Horky J, Riedmüller C, Kampleitner C, Acar E, Fedel M, Höchsmann C, Eskinja M, Mitsche S, Mingler B, Sajti L, Mori G, Bammer M, Walter I, Tangl S, Bergmeister H, Podesser BK, Enayati M.   +17 more
europepmc   +1 more source