Results 221 to 230 of about 71,913,510 (296)

Bacterial Agents and Their Multidrug-Resistance Profile Among Patients Suspected of Bacterial Infections in Hakim Gizaw Hospital, Debre Berhan, Ethiopia: A Cross-Sectional Study. [PDF]

Health Sci Rep
Zelelie TZ, Endewunetu E, Temesgen Y, Gebreyes DS, Sahile Z, Mekonnen B, Bizuneh G, Berihun A, Yitayew B.   +8 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

An S-domain receptor-like kinase regulates auxin distribution and root gravitropism via MPK signaling in Arabidopsis. [PDF]

Plant J
San MM, Zhang C, Peng Y, Chen M, Gallei M, Sun L, Kong M, Friml J, Tan S.   +8 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Correction to "Occurrence and Public Health Implications of Brucella Abortus and Antimicrobial Residues in Raw Cow Milk in Bukombe District, Tanzania". [PDF]

Vet Med Sci
europepmc   +1 more source

Electron-Beam Enables Spatially Resolved Defect-Mediated Work Function Modulation in FAPbI₃ Perovskite Thin Films. [PDF]

Adv Sci (Weinh)
Park H, Choi SG, Kim JH, Lee DJ, Jung SK, Lee G, Kim H, Jin KH, Lee JW, Kim SH.   +9 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Nonstoichiometric Defect Engineering in Mn²⁺-Doped MgGa₂O₄ Persistent Phosphors Toward Enhanced Luminescence and Multimodal Optical Manometry. [PDF]

Adv Sci (Weinh)
Du P, Yu Y, Guo Y, Woźny P, Ma S, Luo L, Runowski M.   +6 more
europepmc   +1 more source