Results 71 to 80 of about 24,931,249 (311)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

(Semantic Web) Services for e-Learning

open access: yes, 2008
Service-Oriented Architectures are becoming a popular system paradigm in e-learning, and there are several efforts to create community driven service frameworks.
Howard, Yvonne   +6 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Other title: System and Services Acquisition Security Controls 2100-13

open access: yes, 2020
[2020 update]; At head of title: DAS Policy; "Effective date: 12/22/2017."; Policy number: 2100-13; "Revision history: 12/22/2017, Original Policy; 12/20/2018, Conducted review, no changes made to the policy as a result; 06/10/2020, Updated the policy ...
Ohio. Department of Administrative Services
core  

New Value-Added Services for Classics E-Journals [PDF]

open access: yes, 2009
This paper examines issues related to electronic journal publishing in the field of Classics with a specific focus on the discussion of new value-added services for e-journals.
Romanello, Matteo
core  

Modeling Medical E-services [PDF]

open access: yes, 2004
On the one hand Web services are gaining increasing attention. A lot of standardization has improved their stability and range of application. Composition and coordination techniques for Web services enable an application integration effort beyond loosely coupled systems.
Rainer Anzböck, Schahram Dustdar
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Designing e-learning services [PDF]

open access: yes, 2009
Recently, increasing numbers of e-learning tools have been developed. However, the benefits of these tools cannot be fully used as they typically operate separately and do not communicate with each other. It is necessary to develop a solution to redeploy
Joy, Mike   +1 more
core  

Assessment of Poland’s national parks in Tripadvisor users’ reviews

open access: yesEconomics and Environment
Nature tourism, including tourism in protected areas, is becoming increasingly important. Since protected areas are traditional and popular tourist destinations, it is advisable that opinions posted about them online should be studied.
Barbara Osóch, Wojciech Zbaraszewski
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

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