Results 161 to 170 of about 337,095 (287)

Neuroprotective Effects of Huperzine B and <i>Huperzia carinata</i> Extract Against MPP⁺-Induced Oxidative Stress in SH-SY5Y Cells. [PDF]

Adv Pharmacol Pharm Sci
Viwatpinyo K, Namchaiw P, Suwanchaikasem P, Mukda S, Tamrakar S, Jaisi A, Warinhomhoun S.   +6 more
europepmc   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Beyond the CO-FT regulatory module: E1 and PHYA emerge as players in photoperiodic regulation of flowering in legumes. [PDF]

J Exp Bot
Henriques R, Benlloch R.
europepmc   +1 more source

Red Blood Cells as Endogenous Biotweezers for Optical Micromanipulation In Vivo

Advanced Science, EarlyView.
By synergistically integrating the long‐distance manipulation fiber probe (LDMFP) and endogenous red blood cells (RBCs) as biocompatible optical elements, a natural RBC biotweezer was developed for the desired microparticle manipulation and immune cell activation within living vasculature, which might offer an alternative tool for intravital optical ...
Tong Yang, Xinyu Ren, Dalin Ma, Hao Pang, Wei Chen, Kaize Cai, Mei Yuan, Bingzhi Zhang, Zufang Lin, Xiaoshuai Liu   +9 more
wiley   +1 more source

A conserved E1 stem motif functions as a virulence switch in the emerging Getah virus. [PDF]

Virulence
Xiang Z, Li G, Wang J, Ma C, Ge X, Gao P, Zhou Q, Guo X, Zhou L, Han J, Zhang Y, Yang H.   +11 more
europepmc   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Optimization of tick identification via MALDI-TOF MS for implementation in routine diagnostics. [PDF]

Parasitol Res
Münch M, Wieser A, Geldmacher C, Kammermeier S, Straubinger RK, Nijhof AM, Maier T, Chitimia-Dobler L.   +7 more
europepmc   +1 more source

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

Mechanical Unloading Inhibits Osteoblast Differentiation via Downregulation of OGT-Mediated O-GlcNAcylation. [PDF]

Curr Issues Mol Biol
Zhao X, Zhang J, Li Z, Sun Q, Xu L, Xue T, Zhao J, Guo X, Zhang R, Xie X, Yan Z, Hu Z, Zhang S, Shi F.   +13 more
europepmc   +1 more source

Intrinsic Phonons as a Dynamic Control Knob for Catalytic Reactivity in 2D Materials

Advanced Science, EarlyView.
Intrinsic phonon excitations are demonstrated to serve as a dynamic control knob for catalytic reactivity in 2D materials. Mode‐selective lattice vibrations reconstruct the electronic structure, lower oxygen evolution reaction barriers, establishing a phonon‐engineering paradigm for dynamically regulating electrocatalysis beyond conventional static ...
Kai Ren, Feifan Wang, Yong‐Wei Zhang, Tianyang Liu, Liangzhi Kou, Yu Jing   +5 more
wiley   +1 more source