Results 201 to 210 of about 419,747 (241)

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Nanoconfinement-Driven Solid-State Ratiometric Fluorescent Aptasensor for 17β-Estradiol Detection in Complex Matrices. [PDF]

Biosensors (Basel)
Zheng S, Wang H, Yu Z, Chen R, Yang L, Xiong B, Tang X.   +6 more
europepmc   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Estrogen-Driven Breast Carcinogenesis in a Rat Model is Linked to Retroelement Activation and Inflammation and is Susceptible to Lamivudine Treatment. [PDF]

Breast Cancer (Dove Med Press)
Evdokimova V, Zhang Z, Ruzanov P, Hung M, Khoshgoo N, Zheng S, Quintayo MA, Stein LD, Bayani J, Radvanyi L.   +9 more
europepmc   +1 more source

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

Understanding Estrogen Circuit-Level Effects Important for Targeted Interventions in Psychiatric Disorders. [PDF]

Biol Psychiatry Glob Open Sci
Milner TA.
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Harmonization and standardization for selection of high-trueness estradiol assay kits in serum and evaluation of estradiol levels relative to follicle diameters on trigger days. [PDF]

Front Med (Lausanne)
Guo M, Wang Z, Chang X, Ren X, Zhang M, Tao Y, Pan H, Wang N, Guo Y, Ding H, Xiao Y, Ke Y, Wu D, Chen X, Wang L, Zhang Q, Zhang Q, Li W.   +17 more
europepmc   +1 more source

From Fluoride Removal to Interfacial Reactivity Enhancement: Functionalized La3+‐Crosslinked B/CuO Energetic Microspheres

Advanced Science, EarlyView.
A fluoride adsorption‐functionalization strategy directly couples fluoride wastewater remediation with combustion performance enhancement of B/CuO energetic microspheres. Fluoride captured from wastewater is retained within the microspheres without adsorbent regeneration or disposal, simultaneously achieving pollutant removal and enhanced energetic ...
Hongbiao Huo, Minghao Bao, Zhongbo Han, Wei Shi, Jianyong Xu, Pengfei Cui, Wenchao Zhang   +6 more
wiley   +1 more source

Phenological Development, Environmental Effects, and Selection of Soybean Lines from Crosses with Contrasting Relative Maturity Groups. [PDF]

Biology (Basel)
Araujo EFB, Cristeli DS, Moitinho ACR, Ferreira FM, Libera DSD, Rodrigues LP, Oliveira MS, Souza JDS, Alliprandini LF, Miranda GV, Unêda-Trevisoli SH.   +10 more
europepmc   +1 more source