Results 211 to 220 of about 419,747 (241)

Intracerebroventricular injection of neuropeptide Y suppresses luteinizing hormone pulses in mice. [PDF]

J Neuroendocrinol
Young LA, Hurtado ER, Jacobs KD, Lee ZMM, Nestor CC, McCosh RB.   +5 more
europepmc   +1 more source

An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs H2O2‐Mediated Plant Defense by Targeting Tomato SlCAT2

Advanced Science, EarlyView.
The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan, Youdan Zhang, Zhujun Wang, Huatao Tang, Huiping Liu, Zi Chen, Shuai Liu, Jiayi Shi, Lu Peng, Youming Hou   +9 more
wiley   +1 more source

Estrogen Withdrawal-Induced Cognitive Impairment in Menopausal Women: Mechanisms and Prospects for Integrated Interventions. [PDF]

Int J Mol Sci
Qiu T, Zhang J, Zhao J.
europepmc   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Automated Tissue Classification and Candidate Biomarker Feature Extraction in Mass Spectrometry Imaging Based on Interpretable Deep Learning Algorithm. [PDF]

Rapid Commun Mass Spectrom
Xu G, Gan S, Guo B, Yang L.
europepmc   +1 more source

Scalable Multilayer PTFE‐Reinforced Membranes for Durable, High‐Current‐Density Hydroxide Exchange Membrane Water Electrolysis in Dilute Alkali

Advanced Science, EarlyView.
Low‐Tg HEMs are designed to improve membrane‐electrode adhesion by promoting intimate contact with catalyst layers. After hydration, the membrane develops a hydrogel‐like network that supports water uptake and ion transport while retaining mechanical robustness.
Zhiwei Ren, Yun Zhao, Rui Zhang, Tao Wei, Yingran Zhu, Yangkai Han, Tongzhou Li, Haitao Zhang, Zhigang Shao   +8 more
wiley   +1 more source

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

Slit-Lamp Evaluation Provides Greater Depth Estimates in Stromal Ulcers Than High-Resolution Ultrasonic Biomicroscopy: A Prospective Study in 50 Dogs. [PDF]

Vet Ophthalmol
Caro-Suarez M, Costa D, Leiva M, Ortillés A, Ortiz G, Villagrasa M, Laguna F.   +6 more
europepmc   +1 more source

DIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT

Advanced Science, EarlyView.
DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...
Hongqiong Li, Liang Cheng, Xiaole Lu, Haonan Dong, Shi Fu, Hongjin Shi, Mingsheng Liu, Chenwei Yang, Yuhang Huang, Zehua Chen, Yawei Zhang, Kaiwen Jie, Xiaoyue Zhang, Xiang Kui, Xinni Ye, Siting Chen, Xu Chen, Haifeng Wang   +17 more
wiley   +1 more source