Results 31 to 40 of about 306,849 (246)

Modeling Local Variations in Intermarriage

Mathematics, 2022
We utilized all Spanish marriage records available at the municipality level from 2005–2007 to model spatial variations in intermarriage. We constructed a spatial regime zero-inflated Poisson model and grouped-data probit model, with spatially lagged ...
Albert Esteve, Coro Chasco, Antonio López-Gay   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Supporting early years L1 and L2 grammar acquisition through an e-learning game: A case study of Estonian go + destination construction

Eesti Rakenduslingvistika Ühingu Aastaraamat
The article describes a pilot Estonian grammar game developed for young learners’ L1 and L2 acquisition of the Estonian go + destination ‘minema + kohasõna’ construction created on the ALPA Kids platform and explores the general possibilities of ...
Kelly Lilles
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Fragmentation of Millimeter-Size Hypervelocity Projectiles on Combined Mesh-Plate Bumpers

Advances in Materials Science and Engineering, 2017
This numerical study evaluates the concept of a combined mesh-plate bumper as a shielding system protecting unmanned spacecraft from small (1 mm) orbital debris impacts.
Aleksandr Cherniaev, Igor Telichev
doaj   +1 more source

Serum Concentrations of AMH and E2 and Ovarian and Uterine Traits in Gilts

Animals, 2019
Poor sow retention due to reproductive failure is a common reproductive inefficiency amongst piggeries. This shows that traditional methods of gilt selection are inadequate and a marker of reproductive success is needed.
Alicia Steel, Rebecca Z. Athorn, Christopher G. Grupen   +2 more
doaj   +1 more source

Macro-level factors explaining inequalities in expected years lived free of and with chronic conditions across Spanish regions and over time (2006–2019)

SSM: Population Health, 2022
Life expectancy has long been associated with macro-level factors, including health expenditures, but little research has focused on the relationship with morbidity measures.
Elisenda Rentería, Pilar Zueras
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Process Map Definition for Laser Metal Deposition of VDM Alloy 780 on the 316L Substrate

Journal of Manufacturing and Materials Processing, 2023
VDM Alloy 780 is a novel Ni-based superalloy that allows for approximately 50 °C higher operating temperatures, compared to Inconel 718, without a significant decrease in mechanical properties.
Pascal Paulus, Yannick Ruppert, Michael Vielhaber, Juergen Griebsch   +3 more
doaj   +1 more source