Results 31 to 40 of about 307,844 (246)
Modeling Local Variations in Intermarriage
Mathematics, 2022 We utilized all Spanish marriage records available at the municipality level from 2005–2007 to model spatial variations in intermarriage. We constructed a spatial regime zero-inflated Poisson model and grouped-data probit model, with spatially lagged ...
Albert Esteve +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Eesti Rakenduslingvistika Ühingu AastaraamatThe article describes a pilot Estonian grammar game developed for young learners’ L1 and L2 acquisition of the Estonian go + destination ‘minema + kohasõna’ construction created on the ALPA Kids platform and explores the general possibilities of ...
Kelly Lilles
doaj +1 more source
Fragmentation of Millimeter-Size Hypervelocity Projectiles on Combined Mesh-Plate Bumpers
Advances in Materials Science and Engineering, 2017 This numerical study evaluates the concept of a combined mesh-plate bumper as a shielding system protecting unmanned spacecraft from small (1 mm) orbital debris impacts.
Aleksandr Cherniaev, Igor Telichev
doaj +1 more source
Serum Concentrations of AMH and E2 and Ovarian and Uterine Traits in Gilts
Animals, 2019 Poor sow retention due to reproductive failure is a common reproductive inefficiency amongst piggeries. This shows that traditional methods of gilt selection are inadequate and a marker of reproductive success is needed.
Alicia Steel +2 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
SSM: Population Health, 2022 Life expectancy has long been associated with macro-level factors, including health expenditures, but little research has focused on the relationship with morbidity measures.
Elisenda Rentería, Pilar Zueras
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Process Map Definition for Laser Metal Deposition of VDM Alloy 780 on the 316L Substrate
Journal of Manufacturing and Materials Processing, 2023 VDM Alloy 780 is a novel Ni-based superalloy that allows for approximately 50 °C higher operating temperatures, compared to Inconel 718, without a significant decrease in mechanical properties.
Pascal Paulus +3 more
doaj +1 more source