Results 241 to 250 of about 504,547 (295)

<i>In silico</i> design and binding mechanism of UBR1 E3 ligase recruiters. [PDF]

RSC Adv
Maria-Solano MA, Lazim R, Choi S.
europepmc   +1 more source

Identifying Systemic Lupus Erythematosus From Serum Proteomic Profiles Using Machine Learning and Genetic Risk Stratification

Arthritis &Rheumatology, Volume 78, Issue 11, Page 2280-2291, November 2026.
Objective Proteome‐wide risk models for lupus remain underexplored. We developed classification models to identify lupus from serum proteomic profiles. Methods Patients with lupus and individuals with other autoimmune diseases in the UK Biobank were included.
Mehmet Hocaoǧlu, Jishnu Das, Amr H. Sawalha   +2 more
wiley   +1 more source

Context matters in PROTAC design: navigating the trade-off between degradation and developability. [PDF]

J Enzyme Inhib Med Chem
Zhang B, Zhang Y, Zhang B, Hu J, Ke C, Wu T, Wei M, Xia J, Wang M, Zhao Q, Tian L, Liang C.   +11 more
europepmc   +1 more source

Müller Glia Subtypes Define Neuro‐Glial Associations and Spatial Morphogen Axes in the Zebrafish Retina

Glia, Volume 74, Issue 11, November 2026.
Zebrafish Müller glia are heterogeneous in the early larval retina. Zebrafish Müller glia subtypes define a spatial axis of retinoic acid metabolism. Neuron‐associated glial programs identified in Zebrafish Müller glia are evolutionarily conserved in mammals. ABSTRACT Müller glia are instrumental macroglia of the vertebrate retina, once thought to be a
Samuel S. Storey, Carrie L. Hehr, Shaelene Standing, Sarah McFarlane   +3 more
wiley   +1 more source

Targeted protein degradation in cancer: strategies for undruggable targets and progress towards clinical translation. [PDF]

Biomark Res
Tang J, Cheng Z, Xie T, Zhuang Y, Hu H, Li C, Wang H, Feng C, Tu C.   +8 more
europepmc   +1 more source

Design of Tissue-Selective PROTACs Through Recruiting E3 Ligase Scaffolding Protein MAGEA11. [PDF]

NPJ Drug Discov
Jacobsen IE, Shi R, Scholtz CR, Pomerantz WCK, Georg GI.   +4 more
europepmc   +1 more source

PRAME Augments K63‐Linked Ubiquitination and Stabilization of METTL3 to Promote Lung Adenocarcinoma Metastasis

MedComm, Volume 7, Issue 11, November 2026.
PRAME promotes lung adenocarcinoma metastasis by inducing K63‐linked ubiquitination of METTL3 at lysine 235, thereby enhancing METTL3 stability and m6A methyltransferase complex assembly. Elevated METTL3 activity increases m6A modification of TGFB2 mRNA, leading to activation of TGF‐β signaling and metastatic progression of lung adenocarcinoma (LUAD ...
Xia Yang, Xuemei Xu, Yaxuan Zhang, Jiamei Guo, Zhiyu Ye, Qiaorui Bai, Xiuqiao Yang, Shujun Liang, Xiang Dong, Xin Zhang, Jiyong Gu, Shuqin Dai, Hongchun Du, Meiwan Chen, Tianyu Tao, Hongyu Guan, Jueheng Wu, Han Tian, Junchao Cai, Mengfeng Li, Xu Li, Yi Yang   +21 more
wiley   +1 more source

Proteomics-Driven Strategies for Proximity-Inducing Drug Discovery. [PDF]

Angew Chem Int Ed Engl
Fan R, Ni J, Zhou T, Jiang H, Zhao W, Tan M.   +5 more
europepmc   +1 more source

Exosomes in Cancer: The Biology, Function, Diagnosis, and Therapy

MedComm, Volume 7, Issue 11, November 2026.
Tumor‐derived exosomes and nonmembranous extracellular nanoparticles (exomeres/supermeres) constitute a heterogeneous communication network that drives cancer progression. By shuttling functional biomolecules across tissue‐specific barriers, these nanoparticles orchestrate local microenvironmental remodeling, immune suppression, premetastatic niche ...
Jun Wu, Lei Wu, Kang Yang, Kang Xie, Tao Lu, Tiangxiang Huang, Dengfeng Wan, Tao Song, Longbo Zhang   +8 more
wiley   +1 more source

The degradation revolution: harnessing targeted protein degradation for the treatment of human diseases. [PDF]

Cell Mol Life Sci
Tong J, Wang P, Ma S, Li J, Zhan Y, Liu M, Jin F, Qu G, Zheng C, Wang X, Wang C.   +10 more
europepmc   +1 more source