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Application of DELs for E3 Ligase Ligand Discovery and Targeted Protein Degradation
Targeted protein degradation (TPD) provides new therapeutic opportunities beyond traditional inhibitors. TPD relies on the ability to induce proximity between an E3 ligase and the target of interest, harnessing the ubiquitin proteasome system to ubiquitylate and degrade the target.Marie L. Malone +3 more
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C-Degron Mimicry Confers E3 Ligase Selectivity
Nature Reviews Molecular Cell Biology, 2023Lisa Heinke
exaly
DISCOVERY OF PIPERLONGUMINE AS A NOVEL E3 LIGASE LIGAND
2023HU WANYI +7 more
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Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules
Nature Structural & Molecular BiologyChristopher M. Hickey +13 more
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Disassembling SCF Ubiqutin Ligases
Nature Reviews Molecular Cell Biology, 2012Katharine Wrighton
exaly
[Transcription factor AhR is a ligand-dependcnt E3 ubiquitin ligase].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2008Fumiaki, Ohtake +2 more
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