Results 101 to 110 of about 72,591 (191)

A Tobacco Homolog of DCN1 is Involved in Cellular Reprogramming and in Developmental Transitions [PDF]

, 2011
Plant proteomes show remarkable plasticity in reaction to environmental challenges and during developmental transitions. Some of this adaptability comes from ubiquitin-mediated protein destruction regulated by cullin-RING E3 ubiquitin ligases (CRLs ...
Alexandra Ribarits, Alisher Tashpulatov, Alisher Touraev, Christina Friedmann, Elisabeth Ankele, Erwin Heberle-Bors, Julia Hosp, Katarzyna Szaszka, Klaus Palme, Marina Baumann, Tatiana Resch, Viktor Voronin, Yongfeng Jin   +12 more
core   +1 more source

The role of HECT-type E3 ubiquitin ligases in inflammation

Frontiers in Immunology
Homologous to the E6-AP Carboxyl Terminus (HECT)-type E3 ubiquitin ligases are key components of the ubiquitin-proteasome system (UPS) and play an important role in the regulation of inflammatory responses. Inflammation serves as a core defense mechanism
Ziyi Wang, Peirui Wang, Huawang Xie, Zhibo You, Xiping Liu, Fang Cao, Shengtao Yao   +6 more
doaj   +1 more source

A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Mat a2 repressor degradation [PDF]

, 2001
Substrate discrimination in the ubiquitin–proteasome system is believed to be dictated by specific combinations of ubiquitin–protein ligases (E3s) and ubiquitin-conjugating enzymes (E2s).
Swanson, Rob
core   +2 more sources

Regulatory Roles of E3 Ubiquitin Ligases and Deubiquitinases in Bone

Biomolecules
E3 ubiquitin ligases and deubiquitinating enzymes (DUBs) are pivotal regulators of bone homeostasis, orchestrating osteoblast differentiation, proliferation, and osteoclast activity by controlling protein degradation and stability. This review delineates
Haotian He, Lifei Wang, Bao Xian, Yayi Xia   +3 more
doaj   +1 more source

Role of the ubiquitin-selective CDC-48/UFD-1/NPL-4 chaperone in DNA replication [PDF]

, 2012
Faithful transmission of genomic information requires tight spatiotemporal regulation of DNA replication factors. Posttranslational modifications, such as ubiquitylation, constitute a fast and effective mechanism to control such complex protein function.
Franz, André
core  

CHARACTERIZATION OF THE UBIQUITIN LIGASE, UBE4B, IN ENDOCYTIC TRAFFICKING [PDF]

, 2017
Endocytosis is a process by which cells internalize membrane proteins to remove them from the plasma membrane, allowing cells to regulate the cell surface expression of transmembrane proteins.
Sirisaengtaksin, Natalie, Sirisaengtaksin, Natalie   +1 more
core   +1 more source

E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy

MedComm
E3 ubiquitin ligases are pivotal regulators within the ubiquitin–proteasome system, conferring specificity to protein ubiquitination and subsequent degradation, thereby maintaining cellular homeostasis.
Haochen Wang, Junbo Peng, Hongchan Li, Yuzhe Lan, Jing Guo, Qiang Qiu, Xuan Huang   +6 more
doaj   +1 more source

Identification of E3 ubiquitin ligase-based molecular subtypes and prognostic signature regarding prognosis and immune landscape in bladder cancer

Cancer Cell International
E3 ubiquitin ligases are acknowledged as the principal catalysts in the ubiquitination process due to their capacity to identify, bind and recruit specific substrates for modification.
Bo Hu, Tong Zhao, Yongshan Li, Kai Li, Luming Shen, Qingyi Zhu, Baojie Ma, Yong Wei   +7 more
doaj   +1 more source

Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity. [PDF]

Nat Commun
Schwartz I, Budroni V, Meyenberg M, Hodakova Z, Hornegger H, Hacker K, Schwartz S, Grabarczyk DB, Ehrmann JF, Scinicariello S, Haselbach D, Menche J, Clausen T, Karagöz GE, Versteeg GA.   +14 more
europepmc   +2 more sources

A structural code for assembly specificity in GID/CTLH-type E3 ligases. [PDF]

Elife
van Gen Hassend PM, Schindelin H.
europepmc   +1 more source