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Inhibitors for E3 ubiquitin ligases
Nature Biotechnology, 2010Two studies show that specific cullin-RING E3 ubiquitin ligases can be targeted with small molecules.
John R Lydeard, J Wade Harper
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E3 ubiquitin ligases in cancer and implications for therapies
Cancer and Metastasis Reviews, 2017E3 ligases are a class of enzymes that can transfer ubiquitin to substrates for their degradation, which are of importance in cellular homeostasis. Since many oncogenic or tumor-suppressive proteins are reported to be regulated by the ubiquitin-proteasome system (UPS), E3 ligases, which function as substrate interacting modules, have been attracting ...
Dong, Wang +4 more
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Role of E3 ubiquitin ligases in insulin resistance
Diabetes, Obesity and Metabolism, 2016E3 ubiquitin ligases are a large family of proteins that catalyse the ubiquitination of many proteins for degradation by the 26S proteasome. E3 ubiquitin ligases play pivotal roles in the process of insulin resistance and diabetes.
X-D, Yang, D-X, Xiang, Y-Y, Yang
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Trim45: An emerging E3 ubiquitin ligases in cancer
Cellular SignallingThe ubiquitin proteasome system is the major pathway for intracellular protein degradation and relies on ATP supply to specifically degrade misfolded or damaged proteins. The system consists of E1, E2, and E3 enzymes that mediate the ubiquitination modification of substrate proteins, followed by proteasomal recognition and degradation of the substrate ...
Huhu, Zhang +9 more
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Systemwide disassembly and assembly of SCF ubiquitin ligase complexes
Cell, 2023Brenda Schulman +2 more
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Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis
Annual Review of Biochemistry, 2021Brenda Schulman
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Wheat RING E3 ubiquitin ligase TaDIS1 degrade TaSTP via the 26S proteasome pathway
Plant Science, 2020Xuejun Li
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