Results 251 to 260 of about 171,834 (303)

The E3 ubiquitin ligase TRIM56 promotes aggregation and activation of Src protein through Lys63-linked polyubiquitination in hepatocellular carcinoma. [PDF]

Cell Death Dis
Zhu L, Cui X, Xu H, Yang M, Han L.
europepmc   +1 more source

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Activation of endogenous PRKN by structural derepression is linked to increased turnover of the E3 ubiquitin ligase. [PDF]

Autophagy
Fiesel FC, Bustillos BA, Watzlawik JO, Chen CXQ, Berryer MH, Zhang J, Boneski PK, Hayes CS, Bredenberg JM, Deneault E, You Z, Abdien N, Aprahamian N, Goldsmith TM, Baninameh Z, Cocker LT, Zhang H, Goldberg MS, Fon EA, Trempe JF, Virdee S, Durcan TM, Springer W.   +22 more
europepmc   +1 more source

Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation

The FEBS Journal, EarlyView.
Structural basis of inactive and active states of the Nedd4 HECT E3 ligase subfamily, following a ‘lock, relax, load, and shoot’ mechanism. In the locked, autoinhibited state, intramolecular domain interactions restrain the HECT domain. Relaxation releases these restraints, allowing loading of ubiquitin onto the catalytic cysteine, followed by the ...
Masa Janosev, Tomas Obsil, Veronika Obsilova   +2 more
wiley   +1 more source

The E3 ubiquitin ligase MARCH2 controls TNF-α mediated inflammation by autoubiquitination. [PDF]

Cell Commun Signal
Chathuranga K, Rathnapala P, Weerawardhana A, Kim TH, Seong Y, Gayan Chathuranga WA, Subasinghe A, Haluwana DK, Gamage N, Choi YJ, Jung JU, Lee JS.   +11 more
europepmc   +1 more source

Rethinking the role of HIF in hepatocellular carcinoma

The FEBS Journal, EarlyView.
Tumor hypoxia is a hallmark of cancer driving disease, in part through activation of hypoxia‐inducible factors (HIFs). While HIF‐1α is classically understood as a hypoxia‐responsive transcription factor, its role under normoxic conditions in cells is less clear.
Niall S. Kenneth, Michael Batie, Sonia Rocha   +2 more
wiley   +1 more source

ETV4 promotes ovarian cancer growth by regulating mitochondrial function through Mfn2 ubiquitination mediated by the E3 ubiquitin ligase MARCH9. [PDF]

Cell Biol Toxicol
Wang Y, Wang Z, Chen J, Cai L, Luo X, Wu N.   +5 more
europepmc   +1 more source

E3 ubiquitin ligase Listerin regulates macrophage cholesterol efflux and atherosclerosis by targeting ABCA1. [PDF]

J Clin Invest
Cao L, Zhang J, Yu L, Yang W, Qi W, Ren R, Liu Y, Hou Y, Cao Y, Li Q, Wang X, Zhang Z, Li B, Sui W, Zhang Y, Gao C, Zhang C, Zhang M.   +17 more
europepmc   +1 more source

The Ac/N-Degron Domain of MARCHF6 E3 Ubiquitin Ligase and Its Role in Regulating Ferroptosis. [PDF]

Cells
Omoniyi H, Hohman G, Eldeeb M.
europepmc   +1 more source

Natural variation of an E3 ubiquitin ligase encoding gene Chalk9 regulates grain chalkiness in rice. [PDF]

Nat Commun
Hu Z, Liu H, Guo M, Han X, Li Y, Chen R, Guo Y, Yang Y, Sun S, Zhou Y, Gu M, Yan C.   +11 more
europepmc   +1 more source