Results 241 to 250 of about 171,834 (303)

E3 ubiquitin ligase BTRC inhibits the proliferation and tumor growth of glioma cells through the NFAT5/AQP4 axis. [PDF]

J Cancer Res Clin Oncol
Li Y, Tang S, Jiang K, Deng P, Hu X.
europepmc   +1 more source

AKR1C3 Binds β‐Trcp to Promote the Degradation of TFRC to Protect Hepatocellular Carcinoma From Ferroptosis

Cancer Science, EarlyView.
In this study, we show that aldo‐keto reductase family 1 member C3 (AKR1C3), a protein highly expressed in ferroptosis resistant hepatocellular carcinoma cells, acts as an enzyme‐independent scaffold protein by promoting the nuclear export of β‐transducin repeat protein (β‐TrCP) and its binding to transferrin receptor (TFRC) in an enzyme‐independent ...
Lei Qi, Jingyi Hua, Di Pan, Wanwan Yang, Geng Tian, Fangyu Ye, Lingxiang Liu, Yuhan Mao, Qinglong Guo, Haopeng Sun, Li Zhao   +10 more
wiley   +1 more source

The E3 ubiquitin ligase SPRYD3-MYCBP2(PAM) regulates mitotic cell fate and ubiquitination of USP11 to control spindle assembly. [PDF]

J Biol Chem
Turi da Fonte Dias AR, Hoffmann I.
europepmc   +1 more source

Challenges and opportunities for the diverse substrates of SPOP E3 ubiquitin ligase in cancer. [PDF]

Theranostics
Yang X, Zhu J, Tao X, Gao F, Cai Y, Lv Y, Xie S, Xie K, Lan T, Han J, Wu H.   +10 more
europepmc   +1 more source

Roles of ER Membrane Protein Complex in Protein Biogenesis and Quality Control in the Lung and Beyond

Cell Proliferation, EarlyView.
The endoplasmic reticulum membrane protein complex (EMC) is an evolutionarily conserved, multi‐subunit transmembrane protein complex crucial to membrane protein biogenesis and cellular protein quality control. This review systematically examines the structure, functions and disease‐associated regulatory mechanisms of EMC across multiple organ systems ...
Yan Qiao, Yuqing Sun, Yutao Huang, Qinghang Meng, Xinhua Lin, Wei Wei, Xiaofang Tang   +6 more
wiley   +1 more source

Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and function. [PDF]

Nat Immunol
Vatovec T, Neehus AL, Jackson KJL, Avery DT, Bagarić I, Erazo L, Arango-Franco CA, Ogishi M, Ahmed SF, Cederholm A, Russell AJ, Della Mina E, Al-Rifai D, Bull R, Buetow L, Sobrino S, Zhang A, Wahlster L, Michelet M, Parvaneh N, Peel J, Barzaghi F, Leardini D, Philippot Q, Saettini F, Dutrieux J, de Muylder B, Vendemini F, Baccelli F, Catala A, Gambineri E, Veltroni M, Pandiarajan V, Aguilar Y, Haerynck F, Elliott M, Turville S, Brillot F, Khan T, Consonni F, Berteloot L, Sewell WA, Rao G, Largeaud L, Conti F, Roullion C, Masson C, Pegoraro F, Ye T, Joubran S, Villalpando E, Bessot B, Seeleuthner Y, Le Voyer T, Rosain J, Li H, Janda Z, Muratore E, Soudée C, Delabesse E, Goulvestre C, Shahrooei M, Puel A, André I, Bole-Feysot C, Abel L, Erlacher M, Béziat V, Lagresle-Peyrou C, Cheynier R, Six E, Marr N, Pasquet M, Alsina L, Goodnow CC, Landegren N, Aiuti A, Zhang P, Masetti R, Huang DT, Ma CS, Casanova JL, Sankaran VG, Bustamante J, Tangye SG, Bohlen J.   +85 more
europepmc   +1 more source

Integrated miRNA–mRNA Analysis Reveals Obesity‐Driven Regulatory Networks in Human Visceral Adipose Tissue With and Without Type 2 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Obesity is characterised by pathological alterations in visceral white adipose tissue (vWAT) that may contribute to the development of type 2 diabetes (T2D). While microRNAs (miRNAs) are key post‐transcriptional regulators, comprehensive human vWAT profiling across metabolic states remains limited.
Elsa Villa‐Fernández, Ana Victoria García, Laura Gallardo‐Nuell, Miguel García‐Villarino, Judit Fernández‐García, Aldara Martin Alonso, Claudia Lozano‐Aida, Lorena Suárez Gutiérrez, Pedro Pujante, Jessica Ares, Tomás González‐Vidal, Raquel Rodríguez Uría, Sandra Sanz Navarro, María Moreno Gijón, Lourdes María Sanz Álvarez, Estrella Olga Turienzo Santos, José Manuel Fernández‐Real, Mario Fernández Fraga, Elías Delgado, Carmen Lambert   +19 more
wiley   +1 more source

A genetic screen identifies the E3 ubiquitin ligase MPSR1 as a suppressor of early flowering of the sensitivity to red light reduced 1 mutant. [PDF]

Sci Rep
Johansson M, Liu W, Steffen A, Vanderwall M, Gendron JM, Staiger D.   +5 more
europepmc   +1 more source

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Expression of Concern: Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition. [PDF]

Cell Cycle
europepmc   +1 more source