Results 221 to 230 of about 231,597 (259)

Comparative Analysis of Salmonella typhimurium‐Induced Transcriptomic Changes in the Spleen of Beijing‐You Chickens and Guang Ming Broilers

Animal Research and One Health, EarlyView.
This study analyzed the spleen transcriptomes of different chicken breeds, identified key differentially expressed genes (EGR1, FOS, and DUSP1) that regulate resistance to Salmonella infection, and elucidated the underlying regulatory mechanisms, thereby providing new targets for disease‐resistant breeding in poultry.
Zixuan Wang, Man Deng, He Geng, Jumei Zheng, Xiang Li, Yaping Wang, Qinghe Li, Guiping Zhao, Qiao Wang   +8 more
wiley   +1 more source

A conserved E3 ubiquitin ligase rewires carotenoid, sterol, and lipid metabolism in <i>Xanthophyllomyces dendrorhous</i>. [PDF]

Proc Natl Acad Sci U S A
Huang R, Wang J, Ding R, Liu Y, Su J, Chen Z, Fan Y, Li F, Wang L, Liu X, Wang S.   +10 more
europepmc   +1 more source

Dual Effects of β‐TrCP2 Deletion in Bone Homeostasis: Suppression of Osteoclastogenesis and Enhancement of Osteoblast Activity

Arthritis &Rheumatology, EarlyView.
Objective The aim of this study was to elucidate the role of beta‐transducin repeat‐containing protein 2 (β‐TrCP2) in bone homeostasis for its potential as a therapeutic target for osteoporosis. Methods The role of β‐TrCP2 in bone phenotypes was investigated using systemic β‐TrCP1 knockout (KO) and β‐TrCP2KO mice, along with myeloid‐specific ...
Woo Jung Kim, Sora Han, Hye In Ka, Sun Young Lee, Jiwon Kim, Hyunjeong Joo, Sujung Soh, Gaeun Oh, Kyung Hyun Yoo, Seung Hyun Han, Yeongkag Kwon, Choogon Lee, Kyung‐Hyun Park‐Min, Se Hwan Mun, Young Yang   +14 more
wiley   +1 more source

A testis-specific E3 ubiquitin ligase complex governs spermiogenesis and male fertility. [PDF]

Nat Commun
Wu T, Tu C, Feng Y, Qu W, Chen J, Wu H, Gao W, Xu B, Yu X, Bao M, Xu J, Zhou N, Hu H, Jiang B, Xie Q, Meng L, Tan C, Lin G, Shen C, Chen X, Guo Y, Zhou T, Liang Y, Hua R, Cao Y, Liu M, Yu J, Huang X, Tan YQ, Zheng B.   +29 more
europepmc   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

E3 Ubiquitin Ligase MDM2 Promotes Growth and CD8⁺ T Cell Dysfunction in Gastric Cancer Through Degradation of SST. [PDF]

J Gastroenterol Hepatol
Yang F, Zhang X, Ji J, Li S, Fang X, Yang L, Guo X.   +6 more
europepmc   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

An RGLG E3 Ubiquitin Ligase CaSIRE1 Negatively Regulates ABA-Dependent Drought Tolerance by Destabilizing CaSAP14 in Pepper. [PDF]

Plant Cell Environ
Choi H, Baek W, Lim CW, Kim DS, Lee SC.
europepmc   +1 more source

Assembly and Maintenance of Myofibrils in the Heart

Cytoskeleton, EarlyView.
ABSTRACT The assembly of actin and myosin to the paracrystalline arrangement of myofibrils in striated muscle, that is, heart and skeletal, has puzzled many a cell biologist. Different models, based on cultured cardiomyocytes, were proposed for the last 30 years to explain the sequence of events.
Elisabeth Ehler
wiley   +1 more source

Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis. [PDF]

Mol Metab
Sachdev V, van Loon NM, Kingma J, Ottenhoff R, Tan JME, van den Berg M, Duijst S, Jongejan A, Levels JHM, Rensen PCN, Kooijman S, de Boer JF, Kuipers F, Kuentzel KB, Kratky D, Kwon Y, Zeigerer A, Hendrix S, Zelcer N.   +18 more
europepmc   +1 more source