Results 231 to 240 of about 231,597 (259)

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

Neuroprotective Role of E3 Ubiquitin Ligase TRIM2 in Parkinson's Disease: Attenuation of Oxidative Stress and Apoptosis via Promoting ELAVL1 Ubiquitination. [PDF]

CNS Neurosci Ther
Liang W, Sun W, Zhao Z, Song K, Jia J.
europepmc   +1 more source

AMOTL2 inhibits lymph node metastasis in gastric cancer by suppressing TGF-β/Smad signaling and is destabilized by the E3 ubiquitin ligase SMURF1. [PDF]

Int J Biol Sci
Wang H, Yang B, Lin C, Wang Y, Lu Y, Li J, Li J, Yu K, Wang M, Liu P, Wang Y, Li Y.   +11 more
europepmc   +1 more source

E3 Ubiquitin Ligase Nedd4-2 Exacerbates Seizure-Induced Mitochondrial Defects in an Alzheimer's Disease Mouse Model. [PDF]

J Neurochem
Wang Y, Zhu J, Lizarazo S, Lee KY, Wong O, Azim S, Yook Y, Kumar V, Tsai NP.   +8 more
europepmc   +1 more source

Serum Starvation Promotes the Proteolysis of OGT by Activating AMPK and the CUL1/SKP1/SKP2 E3 Ubiquitin Ligase in 3T3-L1 Cells. [PDF]

Biomol Ther (Seoul)
Ngo HH, Le DQ, Nam LB, Keum YS.
europepmc   +1 more source

OTULIN protects hyperoxia-induced neonatal lung injury and modulates mitochondrial protein OPA1 in association with the E3 ubiquitin ligase RNF31. [PDF]

Cell Mol Biol Lett
Huang L, Liu Q, Zhang A, Liu Y, Huang F, Wang J, Tan M, Wang D, Zhao M, Wu X.   +9 more
europepmc   +1 more source

Construction of a robust sepsis prognostic classifier based on E3 ubiquitin ligase-related genes. [PDF]

Front Mol Biosci
Xue H, Chen L, Zhao X, Zhu F.
europepmc   +1 more source

The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation

Farnung J, Slobodyanyuk E, Wang PY, Blodgett LW, Lin DH, von Gronau S, Schulman BA, Bartel DP.   +7 more
europepmc   +1 more source

Molecular determinants underlying substrate receptor specificity of human CRL4B E3 ubiquitin ligase

Mohamed WI, Rabl J, Qureshi BM, Leitner A, Uliana F, Kazemzadeh A, Radwan N, Peter M.   +7 more
europepmc   +1 more source

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C-Degron Mimicry Confers E3 Ligase Selectivity

Nature Reviews Molecular Cell Biology, 2023
Lisa Heinke
exaly