Results 11 to 20 of about 67,820 (304)

Comprehensive analysis of the expression and prognosis for RBR E3 ubiquitin ligases in lung adenocarcinoma

Thoracic Cancer, 2022
Background Lung adenocarcinoma (LUAD) is the most common subtype of non‐small cell lung cancer and has a poor prognosis. RBR E3 ubiquitin ligases are a special class of E3 ubiquitin ligases which contain three zinc‐bing domains that catalyze ubiquitin to
Hao Ding, Yuxin Wang, Yuan Cui, Zhike Chen, Yu Li, Jian Yang, Yang Yang, Tengfei Chen, Dian Xia, Chang Li, Chun Xu, Cheng Ding, Jun Zhao   +12 more
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Progress on Poxvirus E3 Ubiquitin Ligases and Adaptor Proteins

Frontiers in Immunology, 2021
Poxviruses have evolved a variety of innate immunity evasion mechanisms, some of which involve poxvirus-encoded E3 ubiquitin ligases and adaptor proteins.
Haoran Cui, Haoran Cui, Haoran Cui, Yaxian Zhang, Yaxian Zhang, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang   +7 more
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Emerging roles of the HECT E3 ubiquitin ligases in gastric cancer

Pathology and Oncology Research, 2023
Gastric cancer (GC) is one of the most pernicious gastrointestinal tumors with extraordinarily high incidence and mortality. Ubiquitination modification of cellular signaling proteins has been shown to play important roles in GC tumorigenesis ...
Aiqin Sun, Aiqin Sun, Xianyan Tian, Yifei Chen, Wannian Yang, Qiong Lin   +5 more
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TRIM56 coiled-coil domain structure provides insights into its E3 ligase functions

Computational and Structural Biotechnology Journal, 2023
Protein ubiquitination is a post-translation modification mediated by E3 ubiquitin ligases. The RING domain E3 ligases are the largest family of E3 ubiquitin ligases, they act as a scaffold, bringing the E2-ubiquitin complex and its substrate together to
Xiaohua Lou, Binbin Ma, Yuan Zhuang, Xiang Xiao, Laurie J. Minze, Junji Xing, Zhiqiang Zhang, Xian C. Li   +7 more
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E3 ubiquitin ligases: styles, structures and functions

Molecular Biomedicine, 2021
E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2.
Quan Yang, Jinyao Zhao, Dan Chen, Yang Wang   +3 more
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Structural studies of the coiled-coil domain of TRIM75 reveal a tetramer architecture facilitating its E3 ligase complex

Computational and Structural Biotechnology Journal, 2022
Protein ubiquitination plays a vital role in controlling the degradation of intracellular proteins and in regulating cell signaling pathways. Functionally, E3 ubiquitin ligases control the transfer of ubiquitin to the target substrates. As a major family
Xiaohua Lou, Binbin Ma, Yuan Zhuang, Xiang Xiao, Laurie J. Minze, Junji Xing, Zhiqiang Zhang, Xian C. Li   +7 more
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From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in Disease

Cells, 2022
The ubiquitin–proteasome system is of fundamental importance in all fields of biology due to its impact on proteostasis and in regulating cellular processes.
Valérie C. Cabana, Marc P. Lussier
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E3 Ubiquitin Ligases in Breast Cancer Metastasis: A Systematic Review of Pathogenic Functions and Clinical Implications

Frontiers in Oncology, 2021
Female breast cancer has become the most commonly occurring cancer worldwide. Although it has a good prognosis under early diagnosis and appropriate treatment, breast cancer metastasis drastically causes mortality.
Yingshuang Wang, Yingshuang Wang, Jiawen Dai, Jiawen Dai, Youqin Zeng, Youqin Zeng, Jinlin Guo, Jinlin Guo, Jie Lan   +8 more
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Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]

, 2012
Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes.
Fulda, Simone, Rajalingam, Krishnaraj, Dikic, Ivan   +2 more
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E3 ubiquitin ligases in the acute leukemic signaling pathways

Frontiers in Physiology, 2022
Acute leukemia is a common hematologic tumor with highly genetic heterogeneity, and many factors are involved in the pathogenesis and drug-resistance mechanism.
Qianru Zhan, Heyang Zhang, Boquan Wu, Naijin Zhang, Lijun Zhang   +4 more
doaj   +1 more source