Results 181 to 190 of about 327,500 (191)

Detection of E6-AP as a potential therapeutic target in cervical specimen of HPV-infected women

Archives of Gynecology and Obstetrics, 2013
Silencing of HPV oncogenes or their human host client proteins using topically applied small interfering RNA (siRNA) may be an attractive nonsurgical strategy for CIN treatment. An exploratory clinical investigation was designed to evaluate E6-AP mRNA expression levels in different stages of cervical intraepithelial neoplasia and during the menstrual ...
Peter, Hillemanns, Matthias, Jentschke, Thomas G, Evans, Philipp, Soergel, Ralf, Hass   +4 more
openaire   +2 more sources

The ubiquitin‐protein ligase E6‐associated protein (E6‐AP) serves as its own substrate

European Journal of Biochemistry, 1998
Recognition of substrate proteins by the ubiquitin‐conjugation system is a highly specific and regulated event and involves the action of ubiquitin‐conjugating enzymes (E2) and ubiquitin‐protein ligases (E3). However, the E2 and E3 involved in the recognition of particular substrates have been identified in only a few cases.
U, Nuber, S E, Schwarz, M, Scheffner
openaire   +2 more sources

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

Cell, 1993
The ubiquitin-dependent proteolytic pathway plays a major role in selective protein degradation. Ubiquitination of proteins requires the sequential action of the ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzymes (E2), and in some cases ubiquitin-protein ligases (E3s).
M, Scheffner, J M, Huibregtse, R D, Vierstra, P M, Howley   +3 more
openaire   +2 more sources

The Roles of E6-AP and MDM2 in p53 Regulation in Human Papillomavirus-Positive Cervical Cancer Cells

Antisense and Nucleic Acid Drug Development, 2000
The p53 tumor suppressor is regulated by the MDM2 oncoprotein through a negative feedback mechanism. MDM2 promotes the ubiquitination and proteasome-dependent degradation of p53, possibly by acting as a ubiquitin ligase. In cervical cancer cells containing high-risk human papillomaviruses (HPV), p53 is also targeted for degradation by the HPV E6 ...
M, Traidej, L, Chen, D, Yu, S, Agrawal, J, Chen   +4 more
openaire   +2 more sources

De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome

Nature Genetics, 1997
Angelman syndrome (AS) is associated with maternal deletions of human chromosome 15q11-q13 and with paternal uniparental disomy for this region indicating that deficiency of an imprinted, maternally expressed gene within the critical interval is the likely cause of the syndrome. Although the gene for E6-AP ubiquitin-protein ligase (UBE3A) was mapped to
T, Matsuura, J S, Sutcliffe, P, Fang, R J, Galjaard, Y H, Jiang, C S, Benton, J M, Rommens, A L, Beaudet   +7 more
openaire   +2 more sources

LOC644656 promotes cisplatin resistance in cervical cancer by recruiting ZNF143 and activating the transcription of E6-AP

Cellular Signalling
Cisplatin resistance remains a persistent challenge in cervical cancer (CC) treatment. Molecular biomarkers have garnered attention for their association with cisplatin resistance in various diseases. Long non-coding RNAs (lncRNAs) exert significant influence on CC development.
Min, Li, Jie, Chen, Hong, Zhang, Yi, Zhang, Jiahui, Wang, Zongji, Shen, Youguo, Chen, Wenjie, Hou, Chi, Chi   +8 more
openaire   +2 more sources

The dual function steroid receptor coactivator/ubiquitin protein-ligase integrator E6-AP is overexpressed in mouse mammary tumorigenesis

Breast Cancer Research and Treatment, 2000
Steroid receptor coactivator and corepressor proteins are important mediators of steroid receptor function. Changes in the expression or activity of these limiting cofactors can contribute to the etiology of steroidal cancers. Using a mouse mammary model of multistage tumorigenesis we have examined whether the expression of select steroid receptor ...
L, Sivaraman, Z, Nawaz, D, Medina, O M, Conneely, B W, O'Malley   +4 more
openaire   +2 more sources

Characterization of the role of E6-AP in Angelman Syndrome and Similar Neurodevelopmental Disorders

2019
openaire   +1 more source

E6-AP Facilitates p300 Recruitment to an Estrogen Responsive Promoter To Allow Efficient Transcription.

2010
HW Catoe, Z Nawaz
openaire   +1 more source

Correction: A Family of Proteins Structurally and Functionally Related to the E6-AP Ubiquitin-Protein Ligase

Proceedings of the National Academy of Sciences, 1995
openaire   +1 more source