Results 141 to 150 of about 129,891 (225)

HPV8-E6 drives coordinated transcriptional and epigenetic reprogramming of keratinocytes. [PDF]

Tumour Virus Res
Hufbauer M, Syed A, Bormann F, Hasche D, Rodríguez-Paredes M, Laine P, Honkimaa A, Auvinen P, Auvinen E, Akgül B.   +9 more
europepmc   +1 more source

4′‐ThioRNA Substitution and Sense‐Strand Segmentation for the Design of Functional Fully Modified siRNAs Targeting SARS‐CoV‐2

Chemistry – A European Journal, EarlyView.
4′‐ThioRNA was broadly tolerated across multiple positions in SARS‐CoV‐2‐targeting siRNAs, but full 4'‐thio modification of both strands caused a reduction in RNAi activity. Sense‐strand segmentation improved RNAi and antiviral activity, particularly when the nick was located at position 10 from the 5′‐end of the sense strand, thereby unlocking the ...
Yuhei Nogi, Jun Tsukimoto, Noriko Saito‐Tarashima, Takaaki Koma, Masako Nomaguchi, Noriaki Minakawa   +5 more
wiley   +1 more source

Current progress and future prospects of chlorin e6 (Ce6) as a therapeutic agent. [PDF]

RSC Adv
Obalola AA, Abrahamse H, Dhilip Kumar SS.   +2 more
europepmc   +1 more source

Targeting Cancer Cells With Self‐Assembled Ru‐Polysaccharide Photocatalyst for Visible‐Light‐Induced Activation of Prodrugs

Chemistry – A European Journal, EarlyView.
Self‐assembled photocatalyst Ru(Ada‐bpy)(bpy)2⊂HACD targets cancer cells and catalyzes the prodrug to drug upon exposure to visible light, providing spatially and temporally control in cancer cells. This strategy achieves efficient, controllable, and targeted activation of prodrugs within cancer cells, laying the foundation of effectively reducing the ...
Jianghua Liu, Dinghao Wu, Alexander Kros, Joost N. H. Reek   +3 more
wiley   +1 more source

Cutaneous papillomaviruses infection rewires fatty-acid metabolism. [PDF]

Front Cell Infect Microbiol
Liu X, Li D, Cai F, Li Y, Wang W, Liao J, Shan S.   +6 more
europepmc   +1 more source

Detection of E6-AP as a potential therapeutic target in cervical specimen of HPV-infected women

, 2014
Silencing of HPV oncogenes or their human host client proteins using topically applied small interfering RNA (siRNA) may be an attractive nonsurgical strategy for CIN treatment.
Hillemanns, P, Hass, R, Jentschke, M, Soergel, P, Evans, TG   +4 more
core  

Persilylated and Related Silyl Anion‐Induced Synthesis of Group 3–10 Metal–Silyl Complexes

Chemistry – A European Journal, EarlyView.
Persilylated and related silyl anions serve as powerful tools for constructing metal–silyl complexes across group 3–10 elements. Their strong σ‐donating ability and steric bulk stabilize low‐coordinate, reactive species and enable unique bonding motifs.
Yusuke Sunada
wiley   +1 more source

MicroRNA Dysregulation in HPV-Driven Cervical Cancer: A Review of Oncoprotein-Targeted Signaling Pathways. [PDF]

Life (Basel)
Pereira GM, Calfa S, Santos PRD, Freitas AJA, Bortoletto SMJ, Reis RM, Marques MMC, Causin RL.   +7 more
europepmc   +1 more source

From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs

Clinical Pharmacology &Therapeutics, EarlyView.
New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug disposition, pharmacological activity, and disease biology that are difficult
Karen Rowland Yeo, Piet H. van der Graaf
wiley   +1 more source

PhoSARte: identification of SARS-CoV-2 phosphorylation sites using contrastive learning and protein language models. [PDF]

Brief Bioinform
Pham NT, Tran DT, Su Q, Jung Y, Bupi N, Kang D, Lee S, Manavalan B.   +7 more
europepmc   +1 more source