Results 71 to 80 of about 129,891 (225)
THE RECOMBINANT ANTIGENS FOR VACCINES FOR THE TREATMENT OF PAPILLOMAVIRUS (REVIEW)
Разработка и регистрация лекарственных средств, 2019 Two licensed vaccines Gardasil and Cervarix, containing main capsid protein L1 virus-like particles antigen, are used for prevention of diseases associated with human papilloma virus.
M. A. Zhuchenko
doaj
UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27
Neurobiology of Disease, 2009 The UBE3A/E6-AP is known to function both as an E3 ubiquitin ligase of the ubiquitin proteasome system and as a transcriptional coactivator. E6-AP shows brain-specific imprinting and loss of function of maternally inherited E6-AP causes Angelman syndrome.
Amit Mishra +2 more
doaj +1 more source
A Drug‐Gated, Modular STAb‐T Immunotherapy With External Control
Advanced Science, EarlyView.Engineered STAb‐TON cells act as programmable living factories that continuously secrete inactive antibody modules, which assemble extracellularly into a functional T cell engager only upon small‐molecule administration. This externally controlled platform enables reversible, on‐demand regulation of antitumor immunity, establishing a new paradigm for ...
Susana Luengo‐Arias +23 more
wiley +1 more source
Caracterización espectroscópica de enmiendas orgánicas
AIA Avances en Investigación Agropecuaria, 2011 Las características estructurales de los ácidos húmicos (ahs) dependen, fundamentalmente, del origen y las condiciones en las cuales se desarrollan estos compuestos.
A. J. Zambrano +3 more
doaj
Nature CommunicationsRealizing practical lithium–sulfur batteries with high energy density requires lean electrolyte design. However, under low electrolyte/sulfur (E/S) ratios, highly concentrated lithium polysulfides in the electrolyte phase limit cycling and capacity. Here,
Hannah Cho +10 more
doaj +1 more source
PLoS Pathogens, 2020 The HECT domain E3 ubiquitin ligase E6AP (UBE3A) is critical for the development of human papillomavirus (HPV) associated cancers, the neurodevelopment disorder Angelman Syndrome, and some cases of autism spectrum disorders.
Camille M Drews +2 more
doaj +1 more source
Detecção molecular do DNA e RNAm do HPV e sua aplicabilidade na triagem do câncer cervical [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2011O câncer de colo uterino representa o segundo tipo de câncer mais comum entre as mulheres.
Martins, Toni Ricardo
core
Overexpression of ligase defective E6-associated protein, E6-AP, results in mammary tumorigenesis
, 2011 E6-associated protein (E6-AP) is a dual function protein. It acts as an E3 ubiquitin-protein ligase enzyme and coactivator of steroid hormone receptors such as estrogen (ERα) and progesterone (PR) receptors.
Sivapriya Ramamoorthy +13 more
core +1 more source
Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants
Advanced Science, EarlyView.Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer +17 more
wiley +1 more source
Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation
Advanced Science, EarlyView.Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu +8 more
wiley +1 more source