Results 61 to 70 of about 28,759 (246)

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

2,3-Dimethoxy-10-oxostrychnidinium 2-(2,4,6-trinitroanilino)benzoate monohydrate: a 1:1 proton-transfer salt of brucine with o-picraminobenzoic acid [PDF]

, 2011
In the structure of the 1:1 proton-transfer compound of brucine with 2-(2,4,6-trinitroanilino)benzoic acid C23H27N2O4+ . C13H7N4O8- . H~2~O, the brucinium cations form the classic undulating ribbon substructures through overlapping head-to-tail ...
Altomare, Bernstein, Białońska, Białońska, Białońska, Białońska, Crocker, Dijksma, Farrugia, Gould, Graham Smith, Oshikawa, Peerdeman, Sada, Sheldrick, Smith, Smith, Smith, Smith, Smith, Spek, Urs D. Wermuth   +21 more
core   +2 more sources

The R.O.A.D. to precision medicine

npj Digital Medicine
We propose a novel framework that addresses the deficiencies of Randomized clinical trial data subgroup analysis while it transforms ObservAtional Data to be used as if they were randomized, thus paving the road for precision medicine.
Dimitris Bertsimas, Angelos Georgios Koulouras, Georgios Antonios Margonis   +2 more
doaj   +1 more source

LA IMPORTANCIA DE LAS POLÍTICAS FISCALES CONTRACÍCLICAS: UNA REVISIÓN TEÓRICA

Revista de la Facultad de Ciencias Económicas, 2023
Antes de la crisis financiera internacional, la atención se centraba en gran medida en la política monetaria, con la política fiscal considerada como secundaria. Sin embargo, la crisis financiera de 2008-09 y la reciente crisis de COVID-19 han destacado la importancia de tener sólidos fundamentos fiscales y la capacidad de implementar políticas ...
openaire   +1 more source

Learning by Necessity: Government Demand, Capacity Constraints, and Productivity Growth

The American Economic Review
This paper studies how firms adapt to demand shocks when facing capacity constraints. I show that increases in government purchases raise total factor productivity in quantity units at the production line level.
Ethan Ilzetzki
semanticscholar   +1 more source

Navigating infection by pathogenic spirochetes: The host‐bacteria interface at the atomic level

Protein Science, Volume 34, Issue 7, July 2025.
Abstract Pathogenic spirochetes bind and interact with various host structures and molecules throughout the course of infection. By utilizing their outer surface molecules, spirochetes can effectively modulate their dissemination, interact with immune system regulators, and select specific destination niches within the host.
Libor Hejduk, Norbert Müller, Adriana Rathner, Ján Štěrba, Shang‐Cheng Hung, Chia‐Lin Chyan, Ryan O. M. Rego, Martin Strnad   +7 more
wiley   +1 more source

Joint Wire Cutting with Non‐Maximally Entangled States

Advanced Quantum Technologies, Volume 8, Issue 5, May 2025.
Wire cutting decomposes large quantum circuits into smaller subcircuits by severing connecting wires, enabling execution on multiple distributed devices. This study employs non‐maximally entangled (NME) states in joint wire cuts to reduce their overhead.
Marvin Bechtold, Johanna Barzen, Frank Leymann, Alexander Mandl, Felix Truger   +4 more
wiley   +1 more source

Understanding the effects of government spending on consumption [PDF]

, 2004
Recent evidence on the effect of government spending shocks on consumption cannot be easily reconciled with existing optimizing business cycle models. We extend the standard New Keynesian model to allow for the presence of rule-of-thumb (non-Ricardian ...
Galí, Jordi, López-Salidoz, J. David, Vallés, Javier   +2 more
core   +1 more source

The Dynamic Response of Municipal Budgets to Revenue Shocks

Social Science Research Network
We study the fiscal and tax response to intergovernmental grants, exploiting quasi-experimental variation within Germany's fiscal equalization scheme triggered by census revisions of population counts. Municipal budgets do not adjust instantly.
I. Helm, Jan Stuhler
semanticscholar   +1 more source

Understanding the influence of digital ecosystems on digital transformation: The OCO (orientation, cooperation, orchestration) theory

Information Systems Journal, Volume 35, Issue 1, Page 368-413, January 2025.
Abstract Digital transformation is a complex, multi‐level phenomenon that still challenges research and practice. Recent research has highlighted the influence of digital ecosystems on digital transformation, but we lack knowledge about how this relationship unfolds across the organisational and the ecosystem levels.
Anna Maria Oberländer, Philip Karnebogen, Patrick Rövekamp, Maximilian Röglinger, Dorothy E. Leidner   +4 more
wiley   +1 more source