Results 41 to 50 of about 2,243,754 (245)

Editing T cell repertoire by thymic epithelial cell-directed gene transfer abrogates risk of type 1 diabetes development

open access: yesMolecular Therapy: Methods & Clinical Development, 2022
Insulin is the primary autoantigen (Ag) targeted by T cells in type 1 diabetes (T1D). Although biomarkers precisely identifying subjects at high risk of T1D are available, successful prophylaxis is still an unmet need.
Fabio Russo   +8 more
doaj   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho   +7 more
wiley   +1 more source

Frozen-Thawed ovarian autografts treated with scaffold-based melatonin delivery in rats

open access: yesReproductive Biology and Endocrinology
Introduction Cryopreserved ovarian tissue transplantation is the only option for fertility preservation in children undergoing cytotoxic treatments.
Luciana Lamarão Damous   +10 more
doaj   +1 more source

Oxidative stress and cell death in cells expressing L-ferritin variants causing neuroferritinopathy

open access: yesNeurobiology of Disease, 2010
Neuroferritinopathies are dominantly inherited movement disorders associated with nucleotide insertions in the L-ferritin gene that modify the protein's C-terminus.
Anna Cozzi   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Online coupling of miniaturized HPLC and high performance thin layer chromatography by a fractionation unit for effect directed analysis

open access: yesAdvances in Sample Preparation
The rising discharge of anthropogenic chemicals into aquatic environments poses a significant threat, necessitating effective monitoring strategies.
Kjell Kochale   +4 more
doaj   +1 more source

Electrophysiological Characterization of the Antarease Metalloprotease from Tityus serrulatus Venom

open access: yesToxins, 2017
Scorpions are among the oldest venomous living organisms and the family Buthidae is the largest and most medically relevant one. Scorpion venoms include many toxic peptides, but recently, a metalloprotease from Tityus serrulatus called antarease was ...
Irene Zornetta   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

The People Demand Social Justice: The Social Protest in Israel as an Agoral Gathering

open access: yesJournal for Perspectives of Economic Political and Social Integration, 2018
The summer of 2011 has seen the first mass-scale social protest in Israel in its 70 years of existence. This social wave that shook the country, showed unique characteristics a-typical of most social and political uprisings, that go largely unexplained ...
Zysberg Leehu
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

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