Results 271 to 280 of about 665,452 (334)

In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses

The FEBS Journal, EarlyView.
Gle1 knockout mice fail to segregate cell lineages at the blastocyst stage, resulting in very early embryonic lethality. Gle1 knock‐in (KI) mice harboring a pathogenic variant giving rise to lethal congenital contracture syndrome 1 show both known and novel innervation defects, supportive of multiorgan pathology in human fetuses.
Tomáš Zárybnický, Sonja Lindfors, Saana Metso, Julia Koivula, Zoltan Szabo, Rasmus Valtonen, Mikko Tulppo, Johanna Magga, Samu Saarimäki, Sonja Bläuer, Ilkka Miinalainen, Risto Kerkelä, Petteri. T. Piepponen, Vootele Voikar, Juho Väänänen, Riikka Kivelä, Bhagwan Yadav, Hanna Lindgren, Pirkko Mattila, Fu‐Ping Zhang, Petra Sipilä, Reetta Hinttala, Satu Kuure   +22 more
wiley   +1 more source

Cognitive and Behavioural Associations of Visual and Hearing Impairments Across the Lifespan in People With Down Syndrome, a Scoping Review

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Hearing and visual impairments are common in individuals with Down syndrome (DS), yet it remains unclear whether sensory impairments are associated with cognitive and behavioural functioning such as language, memory and socialisation. This literature review examines those associations.
Nicolo J. Betoni, Cynthia M. Okamoto, Ira T. Lott, Christy L. Hom   +3 more
wiley   +1 more source

Size, not phylogeny, explains the morphology of the endosseous labyrinth in the crown clade Crocodylia

Journal of Anatomy, Volume 246, Issue 4, Page 558-574, April 2025.
Here, we present the most complete dataset to date on the endosseous labyrinths of extant crocodylians. Using 3D geometric morphometrics, we show that allometry constitutes a major contributor of the shape variation of the crocodylian endosseous labyrinths and that the development of this structure is likely linked to the braincase conformation, in all
Yohan Pochat‐Cottilloux, Gwendal Perrichon, Lionel Hautier, Nicolas Rinder, Romain Amiot, Irena Raselli, Jérôme Adrien, Joël Lachambre, Vincent Fernandez, Jeremy E. Martin   +9 more
wiley   +1 more source

Osteohistological signal from the smallest known phytosaur femur reveals slow growth and new insights into the evolution of growth in Archosauria

Journal of Anatomy, EarlyView.
The paucity of small, skeletally immature individuals representing the earliest ontogenetic stages of extinct archosaurs complicates our understanding of the growth dynamics within and between species. The opportune finding of the smallest phytosaur femora reveals slow growth, a surprising signal considering that larger phytosaurs in North America have
Erika R. Goldsmith, Daniel E. Barta, Ben T. Kligman, Sterling J. Nesbitt, Adam D. Marsh, William G. Parker, Michelle R. Stocker   +6 more
wiley   +1 more source

Semicircular canal morphology in Rodentia and its relationship to locomotion

Journal of Anatomy, EarlyView.
Here, we present a selection of rodent inner ear 3D models in the lateral view, with rodents from seven locomotor categories (left to right: fossorial, semifossorial, semiaquatic, terrestrial, ricochetal, arboreal, and gliding). Semicircular canal (SCC) morphology, including radius of curvature and shape, can be differentiated between specialized forms
Lily Hou, Ornella C. Bertrand, Hiruni N. Mudannayake, Campbell Rolian, Susanne Cote   +4 more
wiley   +1 more source

The evolution of an “owl‐like” auditory system in harriers: Anatomical evidence

Journal of Anatomy, EarlyView.
Harriers hunt relying on sound, with an accuracy to localize sound sources comparable with owls. To assess whether they have owl‐like auditory specializations, we analyzed brain and skull structures using histology and microCT scans. Harriers possess an enlarged external acoustic meatus and significantly expanded auditory brainstem nuclei, up to 12 ...
Sara Citron, Cristian Gutierrez‐Ibanez, Aubrey Keirnan, Vera Weisbecker, Douglas Wylie, Andrew N. Iwaniuk   +5 more
wiley   +1 more source

The cochlear apex demystified: Implications from synchrotron radiation phase‐contrast imaging and microscopy for cochlear implantation

Journal of Anatomy, EarlyView.
This study is the first to present the detailed cellular organization and three‐dimensional (3D) tonotopic arrangement of the human organ of Corti, spiral ganglion, and central modiolus using synchrotron radiation phase‐contrast imaging (SR‐PCI) with matched histological cross‐sections.
Hao Li, Rudolf Glueckert, Anneliese Schrott‐Fischer, Karin Staxäng, Hanif M. Ladak, Helge Rask‐Andersen, Sumit Agrawal   +6 more
wiley   +1 more source

Palaeohistology and life history of the early Palaeocene taeniodont Conoryctes comma (Mammalia: Eutheria)

Journal of Anatomy, EarlyView.
Determining the life histories of mammals after the extinction of the dinosaurs is key to understanding why they rose so quickly to terrestrial dominance. This study analyses growth in a member of a key mammal group that traversed the extinction boundary.
Gregory F. Funston, Zoi Kynigopoulou, Thomas E. Williamson, Stephen L. Brusatte   +3 more
wiley   +1 more source

The hearing capabilities of the Dromornithidae (Aves), with inferences on acoustic communication and ecology

Journal of Anatomy, EarlyView.
The preservation of bony structures which enclose the hearing organs (ECD) provide a basis for interpreting the hearing capabilities of the extinct, flightless Dromornithidae (Aves). Although the length of the dromornithid ECD was especially short, relative to basicranial length, it conformed to the negative allometric scaling relationships observed in
Phoebe L. McInerney, Warren D. Handley, Trevor H. Worthy   +2 more
wiley   +1 more source

Morphometric study of the bony labyrinth of the inner ear in the European moles Talpa europaea, Talpa occidentalis, and Talpa aquitania

Journal of Anatomy, EarlyView.
The study investigates the shape of the semicircular canals in the inner ear of three sister mole species—Talpa europaea, Talpa aquitania, and Talpa occidentalis—using geometric morphometrics on 58 specimens. It finds both interspecific and intraspecific variability in canal morphology, but no evidence of sexual dimorphism.
Alice Melekian, Sergio Daniel Tarquini, Violaine Nicolas, Nathalie Poulet‐Crovisier, Sandrine Ladevèze   +4 more
wiley   +1 more source