Results 71 to 80 of about 5,187 (277)

The influence of habitual protein intake in early childhood on BMI and age at adiposity rebound: results from the DONALD Study [PDF]

International Journal of Obesity, 2006
To analyse the influence of habitual protein intake in early childhood on age and body mass index (BMI) at adiposity rebound (AR), a potential critical period for the development of obesity.A total of 313 children (161 boys, 152 girls) participating in the Dortmund Nutritional and Anthropometric Longitudinally Designed Study.Weighted summary indices ...
A L B, Günther, A E, Buyken, A, Kroke
openaire   +2 more sources

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

A framework for conducting GWAS using repeated measures data with an application to childhood BMI

Nature Communications
Genetic effects on changes in human traits over time are understudied and may have important pathophysiological impact. We propose a framework that enables data quality control, implements mixed models to evaluate trajectories of change in traits, and ...
Kimberley Burrows, Anni Heiskala, Jonathan P. Bradfield, Zhanna Balkhiyarova, Lijiao Ning, Mathilde Boissel, Yee-Ming Chan, Philippe Froguel, Amelie Bonnefond, Hakon Hakonarson, Alexessander Couto Alves, Deborah A. Lawlor, Marika Kaakinen, Marjo-Riitta Järvelin, Struan F. A. Grant, Kate Tilling, Inga Prokopenko, Sylvain Sebert, Mickaël Canouil, Nicole M. Warrington   +19 more
doaj   +1 more source

Nutritional Influences on Adiposity Rebound and Cardiometabolic Outcomes in a Prospective Birth Cohort of Low-Birth-Weight Children: A Study Protocol [version 1; peer review: 2 approved]

Wellcome Open Research
Background Nutritional practices during early life are critical in shaping long-term health outcomes. Poor or inappropriate nutrition may influence adiposity gain and the overall cardiometabolic risk among children born with low birth weight.
Liss Maria Scaria, Sankar Hariharan, Neethu Thulaseedharan, Panniyammakal Jeemon, Deepa Bhaskaran, Srikant Ambatipudi, Arun Gopalakrishnan, Akhila Sureshbabu   +7 more
doaj   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Complications of Cushing's syndrome: state of the art [PDF]

, 2016
Cushing's syndrome is a serious endocrine disease caused by chronic, autonomous, and excessive secretion of cortisol. The syndrome is associated with increased mortality and impaired quality of life because of the occurrence of comorbidities.
Biller, Beverly M. K, Colao, Annamaria, De Martino, Maria Cristina, Isidori, Andrea, Newell Price, John, Pivonello, Rosario   +5 more
core   +1 more source

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

How has child growth around adiposity rebound altered in Scotland since 1990 and what are the risk factors for weight gain using the Growing Up in Scotland birth cohort 1?

BMC Public Health, 2016
Background Adiposity rebound is considered critical to the development of overweight and obesity. The purpose of this study was to investigate how growth has changed in comparison to the UK 1990 BMI growth reference curves between the ages 4–8 years and ...
Lawrence Doi, Andrew James Williams, John Frank   +2 more
doaj   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Insights into infancy weight gain patterns for term small-for-gestational-age babies

Nutrition Journal, 2018
Background Too fast or slow weight gain in infancy is bad for health in later life. In this study, we aim to investigate the optimal weight gain pattern during the first 2 y of life for term small-for-gestational-age (SGA) infants.
Huiqing Shi, Xiaodong Yang, Dan Wu, Xiulian Wang, Tingting Li, Honghua Liu, Chong Guo, Jian Wang, Xiangying Hu, Guangjun Yu, Jinjin Chen   +10 more
doaj   +1 more source