Results 81 to 90 of about 5,187 (277)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

"Mi voglio bene": a pediatrician-based randomized controlled trial for the prevention of obesity in Italian preschool children

Italian Journal of Pediatrics, 2010
Background The first years of life are crucial to start preventive interventions that can have an impact on lifestyle and later overweight and obesity.
Brambilla Paolo, Bedogni Giorgio, Buongiovanni Carmen, Brusoni Guido, Di Mauro Giuseppe, Di Pietro Mario, Giussani Marco, Gnecchi Manuel, Iughetti Lorenzo, Manzoni Paola, Sticco Maura, Bernasconi Sergio   +11 more
doaj   +1 more source

Factors associated with development of excessive fatness in children and adolescents: a review of prospective studies [PDF]

, 2013
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99011/1/obr12035 ...
Colabianchi, N., Condrasky, M. M., Granberg, E. M., Harsha, D. W., Janz, K. F., Lau, E. Y., Liese, A. D., O'Neil, P. M., O'Neill, J. R., Pate, R. R., Taverno Ross, S. E.   +10 more
core   +1 more source

Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self‐Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial‐Host Crosstalk

Advanced Science, EarlyView.
ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai, Siying Cheng, Fengguang Ma, Xiaorong Zhang, Jianan Huang, Zhonghua Liu, Bing Hu   +6 more
wiley   +1 more source

Leptin in early life: A key factor for the development of the adult metabolic profile [PDF]

, 2012
Leptin levels during the perinatal period are important for the development of metabolic systems involved in energy homeostasis. In rodents, there is a postnatal leptin surge, with circulating leptin levels increasing around postnatal day (PND) 5 and ...
Argente, Jesús, Chowen, Julie Ann, Fuente-Martín, Esther, García-Cáceres, Cristina, Granado, Miriam   +4 more
core   +2 more sources

Lower body weight and BMI at birth were associated with early adiposity rebound in 21-hydroxylase deficiency patients

Endocrine Journal, 2016
21-hydroxylase deficiency (21-OHD) is the most common type of congenital adrenal hyperplasia. In addition to the clinical problems caused by adrenal insufficiency and androgen excess, a risk for obesity and metabolic syndrome during young adulthood is a major ramification of the disease.
Shigeru, Takishima, Keisuke, Nakajima, Risa, Nomura, Atsumi, Tsuji-Hosokawa, Nozomi, Matsuda, Yohei, Matsubara, Makoto, Ono, Kentaro, Miyai, Kei, Takasawa, Tomohiro, Morio, Yukihiro, Hasegawa, Kenichi, Kashimada   +11 more
openaire   +3 more sources

Birth outcomes, early growth patterns and age at adiposity rebound: evidence from the Ma’anshan birth cohort (MABC) study

, 2022
Abstract Objective: The age at AR (adiposity rebound) in humans appears to be earlier. Increasing studies found that early age at AR (EAR) are associated with subsequent obesity and related complications, but it is unclear whether birth outcomes and early growth patterns are important factors in AR.
Jixing Zhou, Shanshan Zhang, Yuzhu Teng, Mengting Yang, Shuangqin Yan, Xingyong Tao, Fangbiao Tao, Kun Huang   +7 more
openaire   +1 more source

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

Prenatal Exposure to Traffic Pollution and Childhood Body Mass Index Trajectory

Frontiers in Endocrinology, 2019
Background: Limited evidence suggests an association between prenatal exposure to traffic pollution and greater adiposity in childhood, but the time window during which growth may be most affected is not known.Methods: We studied 1,649 children in ...
Abby F. Fleisch, Abby F. Fleisch, Izzuddin M. Aris, Izzuddin M. Aris, Sheryl L. Rifas-Shiman, Brent A. Coull, Heike Luttmann-Gibson, Petros Koutrakis, Joel D. Schwartz, Itai Kloog, Itai Kloog, Diane R. Gold, Diane R. Gold, Emily Oken, Emily Oken   +14 more
doaj   +1 more source

Macronutrients as sources of food energy. [PDF]

, 2005
This background paper considers the extent to which the development of new recommendations for dietary energy requirements needs to account for the macronutrient (fat, carbohydrate, protein and alcohol) profiles of different diets.
Prentice, Andrew M
core   +1 more source