Results 211 to 220 of about 3,155,969 (318)

Early Printing in America [PDF]

Scientific American, 1890
openaire   +1 more source

Overview of SARS-CoV-2 genomic surveillance in Central America and the Dominican Republic from February 2020 to January 2023: the impact of PAHO and COMISCA's collaborative efforts. [PDF]

Front Public Health
Herrera Agüero S, Sosa A, Martinez AA, Moreno A, Conde Pereira CR, Gonzalez C, Soto-Garita C, Ulate D, Cordero-Laurent E, Brenes H, Sánchez IM, Mendez-Rico J, Góndola J, Molina Mora JA, Leite J, Franco L, Mendoza L, Gresh L, De La Cruz L, Castro Paz M, Barahona M, Iihoshi N, Chavarría O, Born P, Aguillón RM, Vasquez Cordova RC, Gonzalez S, Alvarado Silva SC, Sandoval López X, Imbert Y, Duarte-Martínez F.   +30 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Early aspirin withdrawal versus dual antiplatelet therapy in high-risk patients after percutaneous coronary intervention: Meta-analysis of randomized trials. [PDF]

PLoS Med
Navarese EP, Gurbel P, Tantry U, Talanas G, Grzelakowska K, Umińska J, Jeong YH, Bliden K, Khan SU, Kubica J, Henry TD, Farkouh ME, Kereiakes DJ.   +12 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Analysis of Prevalence and Mortality Among Neonates and Children With Intestinal Atresia: A Multinational Study, 1974-2015. [PDF]

Birth Defects Res
Carreño A, Aguilera MP, Ibañez L, Sarmiento K, Gili JA, Siffel C, Nembhard WN, Bergman JEH, Bermejo-Sánchez E, Tagliabue G, Dastgiri S, Feldkamp ML, Pocius S, Gatt M, Martínez L, Canessa MA, Groisman B, Källén K, Landau D, Lelong N, Morgan M, Arteaga-Vázquez J, Santoroi M, Rissmann A, Sipek A, Szabova E, Wertelecki W, Canfield MA, Mastroiacovo P, Zarante I.   +29 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Cross-national comparison of major depressive disorder burden in China, India, and the United States of America: an age-period-cohort analysis of GBD 2021. [PDF]

Front Psychiatry
Zhang C, Zhang C, Hong X, Xiao Y, Ying W, Ma W.   +5 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source