Results 231 to 240 of about 3,155,969 (318)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Regional Inequities in Mammography Access and Utilization in Latin America: Ethnic, Rural, and Structural Barriers Identified Through a Narrative Review. [PDF]

Epidemiologia (Basel)
Méndez-Domínguez N, Arce Medina MJ, Balam Gomez M, Morales Rojas ME, Novelo Moreno E.   +4 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Higher educational attainment in Huntington disease families: evidence from the Enroll-HD study. [PDF]

Orphanet J Rare Dis
Vazquez JE, Lin D, Mendizabal A, Ogilvie AC, Stuart EA, Garcia TP.   +5 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Population genomics of <i>Anopheles darlingi</i>, the principal South American malaria vector mosquito. [PDF]

Science
Tennessen JA, Brosula R, Chabanol E, Bickersmith S, Early AM, Laws M, Kelley KA, Grillet ME, Gamboa D, Lucas ER, Duchemin JB, Quiñones ML, Sallum MAM, Bergo ES, Moreno JE, Nagi S, Arisco NJ, Sooklall M, Niles-Robin R, Castro MC, Cox H, Gendrin M, Conn JE, Neafsey DE.   +23 more
europepmc   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Association between vaginal washing and group B Streptococcus colonization from periconception through the first trimester of pregnancy in a cohort of Kenyan women. [PDF]

PLoS One
Jisuvei CS, Kinuthia J, Richardson BA, Srinivasan S, Lokken EM, Mandaliya K, Jaoko W, Munch M, Fiedler TL, Fredricks DN, McClelland RS.   +10 more
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Conference: “Spaces of Power and Contestation in Early America, 1607-1865”

Transatlantica
Maïann Stachnik, Marie Rabecq
doaj   +1 more source