Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Universal Early Childhood Interventions: What is the Evidence Base? [PDF]
Universality is a hallmark of Canadian social policy for very young children. The evidence base for these policies is small, non-experimental and offers mixed results.
Baker, Michael
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Supporting translation with early health technology assessment: from definition to action [PDF]
Translating emerging health technologies towards adoption and patient benefit requires timely and effective research and development decisions. Early health technology assessment has a key role to play in supporting these decisions.
Gavan, Sean
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Cash Transfers, Behavioral Changes, and Cognitive Development in Early Childhood: Evidence from a Randomized Experiment [PDF]
Cash transfer programs have become extremely popular in the developing world. There is a large literature on the effects of these programs on schooling, health and nutrition, but relatively little is known about possible impacts on child development ...
Karen Macours +2 more
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Women’s Pension Rights and Survivors’ Benefits: A Comparative Analysis of EU Member States and Candidate Countries. ENEPRI Research Reports No. 53, 22 April 2008 [PDF]
, 2008 This report presents and compares old-age income provision rules with respect to the issue of equality between women and men in the current and future EU member states.
Ruzik, Anna +2 more
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Acceptance Of Indirect Comparisons In The German Early Benefit Assessment [PDF]
Value in Health, 2017 F Berkemeier +4 more
openaire +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Integrated life-cycle assessment of electricity-supply scenarios confirms global environmental benefit of low-carbon technologies [PDF]
, 2014 Integrated life-cycle assessment of electricity-supply scenarios confirms global environmental benefit of low-carbon technologies / Edgar G. Hertwich, et al.
Danièle Revel
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