Results 131 to 140 of about 704,542 (298)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

A cost-benefit assessment of compressed natural gas [PDF]

open access: yes, 1983
Full text is available to authenticated members of The University of Auckland only.New Zealand has embarked on a major investment programme in the supply and use of compressed natural gas (CNG) as a motor fuel.
Ellis, Murray J. (Murray Judson), 1943-
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Exploring beneficiary perceptions about the use of refurbished container classrooms for early childhood development in vulnerable communities in the Westen Cape [PDF]

open access: yes, 2014
This study explored beneficiary perceptions about the use of refurbished container classrooms for Early Childhood Development (ECD) in vulnerable communities in the Western Cape.
Mwape, Christine
core  

BOOK REVIEW: Encyclopedia of Language and Education: Language Testing and Assessment (3rd ed.)

open access: yesIranian Journal of Language Teaching Research, 2018
Taking the important role of testing and assessment from social, political, professional, ethical, and educational dimensions, the Encyclopedia of Language and Education: Language Testing and Assessment (3rd ed.)covers the innovative methodologies and ...
Zainab Abolfazli, Karim Sadeghi
doaj  

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

Multimodal integration for Barrett’s esophagus

open access: yesiScience
Summary: The esophageal adenocarcinoma is facing a worldwide challenge: early prediction and risk assessment in clinical Barrett’s esophagus (BE). In recent years, the growing interests have been witnessed in prediction and risk assessment in clinical BE.
Shubin Liu   +4 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

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