Results 71 to 80 of about 582,473 (264)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Clinicopathological features and impact on surgical axillary management of encapsulated papillary carcinoma of the breast

Discover Oncology
Background Encapsulated papillary carcinoma (EPC) is a rare breast malignancy accounting for approximately 0.5–1% of all breast cancers. Although generally associated with favorable outcomes, the presence of invasive carcinoma may influence axillary ...
Yasmine Hany Abdel Moamen Elzohery, Ahmed Orabi, Galal Ghaly, Neveen Gamal Fathy Ali, Eman Ali Khalaf, Hazem Abdelazim, Sherif Nasser Taha, Mohamed Fathy Abdelfattah Abdelrahman Elithy   +7 more
doaj   +1 more source

Clinicians’ experiences and perspectives of breast cancer and possible integration of breast cancer prevention and early detection into palliative care

International Journal of Africa Nursing Sciences, 2019
Background: Late presentation of breast cancer (BC) is a public health concern due to its impact on survival and mortality, especially, in low-resourced countries.
Adwoa Bemah Bonsu, Purity Busisiwe Ncama
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Pembentukan Kader GPS2 (Gerakan Perempuan Sehat dengan SADARI) Sebagai Upaya Peningkatan Cakupan Deteksi Dini Kanker Payudara

Caradde
The purpose of this community service is to improve the knowledge and attitudes of adolescents and women of childbearing age about breast cancer, and to increase the motivation of women of childbearing age to perform early detection of breast cancer with
Aim Matun Nadhiroh, Irma Maya Puspita, Asta Adyani, Awwalul Wiladatil Qodliyah, Annisa’ Wigati Rozifa   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

A comparative study between the diagnostic performance of contrast-enhanced digital mammography and dynamic contrast-enhanced MRI in invasive lobular carcinoma of the breast

The Egyptian Journal of Radiology and Nuclear Medicine
Background Invasive lobular carcinoma is the second most prevalent histological subtype of breast cancer after invasive duct carcinoma, with a reported increased incidence in the last two decades.
Sherihan Fakhry, Rasha Mohamed Kamal, Omnia Mokhtar Nada, Amira Emad Abo El Enien Mohamed, Mennatallah Mohamed Hanafy   +4 more
doaj   +1 more source

Hot Issues in Internal Medicine Treatment for HER2 Positive Early Breast Cancer Reflected in the 2019 St. Gallen International Breast Cancer Conference

Zhongliu Fangzhi Yanjiu, 2019
The 16th St. Gallen International Breast Cancer Conference was held in Vienna, Austria from March 20, 2019 to March 23, 2019. The biennial St. Gallen International Breast Cancer Conference and Expert Consensus present an inventory and summary of the ...
ZHENG Yabing, YU Yang, WANG Xiaojia
doaj   +1 more source