Results 101 to 110 of about 6,996,922 (272)

An easy way to improve lab meetings

eLife
Sharing positive and negative experiences at lab meetings can make a career in science a little less hard, a little more pleasant, and a little more human.
Cara Glynn, Tiago Monteiro
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Designing a collective prototype of future (sub)tropical science

FACETS
Ecologists coming from certain countries are currently disfavoured on the peer review process, the recognition of their research products and academic labour, and the lack of leadership opportunities in global settings.
Gracielle T. Higino, Krishna Anujan, Mickey Boakye, M. Eugenia Degano, Norma-Rocio Forero-Muñoz, Tanya Strydom   +5 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Tackle “Molecular Engine” by early-career researchers

Biophysics and Physicobiology, 2022
Akihiro Otomo, Takahiro Kosugi
doaj   +1 more source

The Ethics of Excellence in Tourism Research: A Reflexive Analysis and Implications for Early Career Researchers

, 2018
Set against the framework of today's competitive research environment, this article focuses on a less discussed category of ethics within tourism: that of the researcher as a professional.
Catheryn Khoo-Lattimore, Khoo-Lattimore, C   +1 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Towards a praxis of care in post-pandemic fieldwork: Comparing ethnographic encounters during Covid-19

SSM: Qualitative Research in Health
The Covid-19 pandemic has highlighted the importance of ensuring the wellbeing of both researchers and participants throughout the research process. In this paper, we argue that in order to produce caring research, the wellbeing of researchers must not ...
Ana-Maria Cîrstea, Lucy Johnson, Chimwemwe Phiri   +2 more
doaj   +1 more source

Guidelines for ensuring meaningful engagement of early career researchers in scientific collaborations: recommendations from and for marine and polar scientists [PDF]

There is an increasing recognition of the importance of involving early career researchers (ECRs) in scientific positions of trust within national and international organizations, collaborative research projects, networks, and working groups.
Erinosho, B.
core   +1 more source