Results 81 to 90 of about 6,996,922 (272)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Navigating Open Research - A Guide for Early Career Researchers [PDF]

Welcome to Navigating Open Research – A Guide for Early Career Researchers. This guide is designed to help you at each stage of your research journey. From preparing your research project and discovering relevant resources (Section 1) to research data management and reproducibility (Section 2), writing and publishing (Section 3), sharing and publishing
Aoife Coffey, Cillian Joy, Ashling Hayes, Grainne McCabe, Liam O'Dwyer, Eoin McCarney, Rebecca Clarke, Frances Madden, Diarmuid Stokes, Ciarán Quinn, Michelle Dalton, Elizabeth Noonan   +11 more
openaire   +3 more sources

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

‘A double-edged sword. This is powerful but it could be used destructively’: Perspectives of early career researchers on learning analytics

Frontline Learning Research, 2018
Learning analytics has been increasingly outlined as a powerful tool for measuring, analysing, and predicting learning experiences and behaviours. The rising use of learning analytics means that many educational researchers now require new ranges of ...
Jenna Mittelmeier, Rebecca L. Edwards, Sarah K. Davis, Quan Nguyen, Victoria L. Murphy, Leonie Brummer, Bart Rienties   +6 more
doaj   +1 more source

Stern review leaves early-career researchers cold

, 2016
Early-career researchers took to Twitter following the publication of Nicholas Stern’s review of the Research Excellence Framework, wondering if changes being proposed would prevent them from moving between ...
Eve, Martin Paul, McKenzie, Lindsay
core  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Challenges Faced by Early-Career Researchers in Academia: A Narrative Review of Structural Barriers and Support Strategies

Journal of Practical Emergency Medicine
Early-career researchers (ECRs) occupy a heterogeneous set of career stages, from doctoral training and postdoctoral appointments to the transition toward independent research leadership.
Khaled Moghib, Abdallah Abunamoos
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source