Results 71 to 80 of about 6,996,922 (272)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Can lifestyle preferences help explain the persistent gender gap in academia? The "mothers work less" hypothesis supported for German but not for U.S. early career researchers. [PDF]

PLoS ONE, 2018
Do lifestyle preferences contribute to the remaining gender gap in higher positions in academia with highly qualified women-especially those with children-deliberately working fewer hours than men do?
Monika Sieverding, Constanze Eib, Andreas B Neubauer, Thomas Stahl   +3 more
doaj   +1 more source

RAISE Special Interest Groups (Early Career Researchers and Research & Evaluation) Collaboration: A Case Study [PDF]

In the academic year 2022/23, the RAISE Special Interest Groups for Early Career Researchers and Research & Evaluation collaboratively developed a professional development programme for HE colleagues new to writing about student engagement.
Wilko Luebsen, Stuart Sims, John Lean, Kim Sum   +3 more
core   +4 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Twin Ports Early-Career Researchers Fall Forum & Workshop (2019-10-29)

, 2019
October 29|2019; University of Minnesota - Duluth; Library Rotunda; +Workshop|Networking for scientists (10:30-12:30); +Career Panel Discussion|Applying, interviewing, & negotiating (1:30-3:30); +Keynote|Science as a business and mapping your career (3 ...
Twin Ports Early-Career Researchers
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Nurturing Peer Review Proficiency in the Curriculum for Early Career Medical Researchers: Fostering Academic Connectivity

Journal of Indian Association of Public Health Dentistry
Peer review is being criticized for its sluggishness and review quality. Swiftly identifying available reviewers and cultivating a pool of specialized experts is crucial to avoid delays and ensure a seamless peer review process.
Amit Kumar, Manjunath P. Puranik
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Text recycling and dissertation overlap in the era of open access [PDF]

European Science Editing
As doctoral theses become increasingly accessible through open repositories and similarity-checking software is applied more widely, many early-career researchers encounter the rejection of manuscripts that are legitimately derived from their theses ...
Olivier Pourret
doaj   +3 more sources

Reflections on mentorship as an early career researcher

Molecular Biology of the Cell, 2022
It is my great honor to receive the 2022 Günter Blobel Early Career Award from the American Society for Cell Biology. Reflecting upon my research and career trajectory, I recognize the incredible support of my mentors and the hard work of everyone within my lab.
openaire   +2 more sources