Results 61 to 70 of about 1,671 (203)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Navigating Open Research - A Guide for Early Career Researchers [PDF]

Welcome to Navigating Open Research – A Guide for Early Career Researchers. This guide is designed to help you at each stage of your research journey. From preparing your research project and discovering relevant resources (Section 1) to research data management and reproducibility (Section 2), writing and publishing (Section 3), sharing and publishing
Aoife Coffey, Cillian Joy, Ashling Hayes, Grainne McCabe, Liam O'Dwyer, Eoin McCarney, Rebecca Clarke, Frances Madden, Diarmuid Stokes, Ciarán Quinn, Michelle Dalton, Elizabeth Noonan   +11 more
openaire   +3 more sources

Reflections on mentorship as an early career researcher

Molecular Biology of the Cell, 2022
It is my great honor to receive the 2022 Günter Blobel Early Career Award from the American Society for Cell Biology. Reflecting upon my research and career trajectory, I recognize the incredible support of my mentors and the hard work of everyone within my lab.
openaire   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

‘A double-edged sword. This is powerful but it could be used destructively’: Perspectives of early career researchers on learning analytics

Frontline Learning Research, 2018
Learning analytics has been increasingly outlined as a powerful tool for measuring, analysing, and predicting learning experiences and behaviours. The rising use of learning analytics means that many educational researchers now require new ranges of ...
Jenna Mittelmeier, Rebecca L. Edwards, Sarah K. Davis, Quan Nguyen, Victoria L. Murphy, Leonie Brummer, Bart Rienties   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Challenges Faced by Early-Career Researchers in Academia: A Narrative Review of Structural Barriers and Support Strategies

Journal of Practical Emergency Medicine
Early-career researchers (ECRs) occupy a heterogeneous set of career stages, from doctoral training and postdoctoral appointments to the transition toward independent research leadership.
Khaled Moghib, Abdallah Abunamoos
doaj   +1 more source