Results 221 to 230 of about 7,542,497 (361)

PVC Nanoplastics Exposure Exacerbates Asthma through R‐Loop Accumulation and Subsequent STING Activation in Macrophages

Advanced Science, EarlyView.
Polyvinyl chloride (PVC) nanoplastics (NPs) are shown to aggravate allergic airway inflammation in asthma by triggering R‐loop accumulation and activating the cGAS‐STING pathway in macrophages. This study reveals a novel immunotoxic mechanism linking environmental plastic exposure to asthma pathogenesis and highlights potential molecular targets for ...
Qimei Bao, Yixing Huang, Mingcong Deng, Chunkai Zhang, Dan Zu, Hanyi He, Yangchan Hu, Yuke Zhong, Chen Liang, Haidong Liu, Wumin Dai, Yanhua He, Yaoshu Teng, Ji Jing, Yin Shi, Xiangdong Cheng, Zu Ye   +16 more
wiley   +1 more source

Application of machine learning in early childhood development research: a scoping review. [PDF]

BMJ Open
Benson FN, Chelangat D, Brink W, Mwangala PN, Waljee AK, Moyer CA, Abubakar A.   +6 more
europepmc   +1 more source

Thrombotic and hemorrhagic strokes complicating early therapy for childhood acute lymphoblastic leukemia

, 1980
John R. Priest, Norma K.C. Ramsay, Richard E. Latchaw, Lawrence A. Lockman, Duane K. Hasegawa, Thomas D. Coates, Peter F. Coccia, J. Roger Edson, Mark E. Nesbit, William Krivit   +9 more
openalex   +1 more source

Investing in the foundation of sustainable development: pathways to scale up for early childhood development

The Lancet, 2017
L. Richter, B. Daelmans, J. Lombardi, J. Heymann, F. Boo, Jere R. Behrman, Chunling Lu, J. Lucas, R. Pérez‐Escamilla, T. Dua, Z. Bhutta, K. Stenberg, P. Gertler, G. Darmstadt   +13 more
semanticscholar   +1 more source

A Novel Cultivation System for Germ Cell Proliferation and Sustaining Whole Testicular Niche

Advanced Science, EarlyView.
A hydrogel microneedle‐based system enables whole testicular cultivation, supporting spermatogonial proliferation and enhancing spermatogenesis in vitro. This ‘whole testicular spermatogonia pool’ (WTSP) significantly increases spermatid production and fertility potential in mice. This system also promotes spermatogonial expansion in human fetal testes,
Yu Xia, Xiaoxuan Zhang, Bohang Zhang, Minhui Lu, Qing Cheng, Li Liu, Lifang Shi, Yiqiang Cui, Dingdong Chen, Laihua Li, Xuejiang Guo, Jingtao Guo, Jiahao Sha, Yuanjin Zhao, Yan Yuan   +14 more
wiley   +1 more source

Epigenetic age acceleration and psychosocial stressors in early childhood. [PDF]

Epigenomics
Mulligan CJ.
europepmc   +1 more source

Early Childhood Education, Charles Desforges (editor) (Scottish Academic, Press, 1989), pp. xii + 166, £9.50 [PDF]

, 1990
Jaci Wilkinson
openalex   +1 more source

Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop

Advanced Science, EarlyView.
The protein levels of deubiquitinating enzyme A (DUBA) are rapidly upregulated in microglia after activation of Toll‐like receptor 4 (TLR4). In turn, DUBA potentiates TLR4‐induced proinflammatory signal transduction in microglia by stabilizing interleukin‐1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination.
Zhenhu Zhu, Zhongding Li, Kate Lykke Lambertsen, Zijun Cao, Meng Chen, Yanqi Xu, Bettina Hjelm Clausen, Keshuo Jin, Yiting Lu, Fuqi Mei, Xue Du, Kangmin Chen, Huiyuan Bai, Xian Su, Bincheng Zhou, Baohua Liu, Ran Li, Chaoqun Wang, Yuhua Li, Xiang Cai, Dirk Schlüter, Weihong Song, Xu Wang   +22 more
wiley   +1 more source

Early childhood risk and protective factors and their association with adolescent sexual behaviors: A Latent Class Analysis. [PDF]

PLoS One
Liu Q, Vasilenko SA, Wang X, Razza RA.
europepmc   +1 more source

Early childhood infection and atopic disorder [PDF]

, 1998
I. Sadaf Farooqi, J. M. Hopkin
openalex   +1 more source