Results 71 to 80 of about 19,292,946 (265)

Time Will Prove Everything—專業認同對準教保員生涯適應力與時間距離之研究 Time Will Prove Everything: Professional Identity’s Effect on Career Adaptability and Temporal Distance in Pre-child Caregivers

Journal of Research in Education Sciences
本研究旨在探討幼保相關科系準教保員之生涯適應力與專業認同之關聯，並分析其影響機制與關鍵因素，進一步考察時間距離對專業認同與生涯適應力間關係的調節角色。研究以Savickas（2013）提出的生涯適應力理論為基礎，探討「生涯好奇」是否透過「生涯控制」與「生涯關注」的中介，促進「生涯信心」之形成，並檢驗專業認同在其中的調節效果。同時，亦納入時間距離（近程與遠程目標）作為預測變項，以區別分析評估其對專業認同傾向的解釋力。研究以1,158名幼保相關科系學生（準教保員）為樣本，採調節式中介分析。結果顯示 ...
邱華慧 Hua-Huei Chiou, 何函儒 Han-Ju Ho   +1 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The views and experiences of Grade 3 teachers in developing learners’ algebraic representations

Pythagoras
The global concern over low mathematical achievement consistently challenges educational ministries. Poor development of learners’ algebraic representations contributes to poor mathematical achievement from the Foundation Phase classes (Grades 1–3).
Mmakgabo A. Selepe, Thembi A.L. Phala
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The communication accretion spiral : a communication process for promoting and sustaining meaningful partnerships between families and early childhood service staff

, 2005
Findings of an investigation of parents' perceptions of early childhood service quality identified limitations in staff-parent communication which inhibit the development of a shared parent and staff approach to children's care and education.
Elliott, Roslyn
core  

Re-thinking pedagogies: New immigrants in Aotearoa New Zealand early childhood settings [PDF]

, 2014
This chapter examines the importance of teacher orientations towards immigrant children, families, and teachers in early childhood education settings in Aotearoa New Zealand.
Arndt, Sonja Kathrina, Arndt, Sonja
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Learning with Online Teaching Video Cases: Investigating Pre-Service Preschool Teachers’ Perceived Usefulness and Needs

Education Sciences
Extensive empirical research has emphasized the benefits of integrating Online Teaching Video Cases (OTVCs) into pre-service preschool teacher education.
Rongrong Xu, Alfredo Bautista, Weipeng Yang   +2 more
doaj   +1 more source

Mothers' perspectives on learning through play in the home

, 2016
Research in the field of early childhood education and care (ECEC) indicates that if educators can align their perspectives and practices with families' perspectives, children's educational outcomes will improve.
Colliver, Yeshe
core