Results 101 to 110 of about 9,208,125 (300)

Nurses' role in early detection of cataracts

, 2015
Cataracts are a common problem but can have a significant negative impact on an person’s functional abilities and emotional wellbeing. This article provides nurses with an insight into how age-related cataracts develop and clarifies which symptoms to ...
Craig, Stephen
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Linkable, Polycarbonate Gut Microbiome‐Distal Tumor Chip Platform for Interrogating Cancer Promoting Mechanisms

Advanced Science
Gut microbiome composition is tied to diseases ranging from arthritis to cancer to depression. However, mechanisms of action are poorly understood, limiting development of relevant therapeutics.
Danielle S.K. Brasino, Sean D. Speese, Kevin Schilling, Carolyn E. Schutt, Michelle C. Barton   +4 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Assessment of barriers to the cervical cancer continuum and existing interventions in 5 African countries

BMC Public Health
Background Several studies have been conducted in Africa on barriers to cervical cancer screening from the individual and the healthcare professional perspective, while the existing interventions to overcome these barriers have been seldom reported.
Isabel Mosquera, Arunah Chandran, Mary Luz Rol, Adie Yao Mesmin Olivier, Yacubu Bakare Herve Julius, Takelech Moges Asnake, Frank Rwabinumi Mugabe, Bridget Kebirungi, Mwate Joseph Chaila, George Pupwe, Bothwell Takaingofa Guzha, Ndabaningi Simango, Sharon Kapambwe, Jean Marie Dangou, Partha Basu, Andre Lopes Carvalho   +15 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Experimental Analysis on Effectiveness of Confocal Algorithm for Radar Based Breast Cancer Detection [PDF]

, 2012
Breast cancer is one of the most commonly diagnosed cancers in females in UK [1]. Early breast cancer detection which has recently been gaining a lot of consideration within the research community and the most important for a quick and effective ...
ABDUL-SATTAR, ZUBAIDA
core  

Integrating a “see-and-treat” approach with opportunistic human papilloma virus deoxyribonucleic acid (HPV DNA) based cervical cancer screening in India: a retrospective cross-sectional studyAJOG Global Reports at a Glance

AJOG Global Reports
BACKGROUND: India lacks an organized national cervical cancer screening program, and while the World Health Organization (WHO) recommends human papillomavirus (HPV) deoxyribonucleic acid (DNA) testing as the primary modality, large-scale evidence on ...
Sripriya Rao, BE, Mayank Chhabra, MPH, MBA, Jagadish Kudkuli, PhD, Milan Toraskar, MBA, Aswathy G. Nath, MS, DNB, Devu Prakash, MBBS, Shweta Srivastava, MBA, Wahengbam Imo Singh, MSW, Malini Chandrasekharan, MBBS, DO, Kunal Oswal, MPH, Jaganjeet Randhawa, BDS, MPH, Venkataramanan Ramachandran, PhD   +11 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source