Results 181 to 190 of about 1,977,831 (264)

Early Detection of Spoofing Threats and Network Resilience Prediction in Drones Based on GRU and LSTM. [PDF]

Sensors (Basel)
Oh C, Youn J, Ryu W, Kim K.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Amyloid spatial extent with florbetapir-PET for early detection of preclinical Alzheimer's disease. [PDF]

J Prev Alzheimers Dis
Thibault EG, Del Carmen Montenegro G, Becker JA, Price JC, Healy BC, Hanseeuw BJ, Buckley RF, Jacobs HIL, Properzi MJ, Sperling RA, Johnson KA, Farrell ME.   +11 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

An integrated framework for early detection and transmissibility assessment of emerging variants in wastewater. [PDF]

Int J Hyg Environ Health
Chen X, Phan T, Lee WL, Clark K, Rhode SF, Brozak S, Pell B, Palden T, Leifels M, Gitter A, Kuang Y, Wuertz S, Thompson J, Mena KD, Alm EJ, Wu F.   +15 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Immune Checkpoint Inhibitor-Induced Endocrine Dysfunction: Early Detection of Symptoms and Timely Intervention. [PDF]

Clin Case Rep
Obaed NG, Fofana K, Matarneh A, Sardar S, Trivedi N, Ghahramani N.   +5 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A Roadmap to Transform Lung Cancer Outcomes: Priorities in Biology, Therapeutic Innovation, Early Detection, Prevention, and Interception. [PDF]

Cancer Discov
Winslow MM, Ahmed MA, Berg CD, Black JRM, Downward J, Govindan R, Herbst RS, Heymach JV, Jaffee EM, Kraut N, Merad M, Meyerson M, Pandya T, Politi K, Rao AV, Rudin CM, Soria JC, Tang YJ, Wong KK, Yap TA, Swanton C, AACR Lung Cancer Task Force.   +21 more
europepmc   +1 more source