Results 181 to 190 of about 9,208,125 (300)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Handwriting as a Biomarker for Early Detection of Parkinson's and Alzheimer's Diseases: A Comprehensive Guide for Researchers. [PDF]

Sensors (Basel)
Bensefia A, Al Hashlamoun N.
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Increasing participation of underrepresented groups in cancer early detection research: a scoping review. [PDF]

Front Public Health
Brockhoven F, Raphael M, Pashayan N, Arteaga I.   +3 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Early Detection [PDF]

, 2020
openaire   +2 more sources

Kenya's integrated program for cervical and breast cancer's early detection. [PDF]

Int J Gynecol Cancer
Sangara D, Varon M, Fitzgerald E, Lilian G, Bor JP.   +4 more
europepmc   +1 more source

The Early Detection of Pyrexia in the Newborn [PDF]

Archives of Disease in Childhood, 1963
openaire   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Longitudinal CT Scanning for Explainable Early Detection of Postharvest Disorders: The 'Braeburn' Browning Case. [PDF]

J Imaging
Schut DE, Wood RM, Schouten R, van Liere R, van Leeuwen T, Batenburg KJ.   +5 more
europepmc   +1 more source