Results 61 to 70 of about 9,208,125 (300)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Cell free RNA detection of pancreatic cancer in pre diagnostic high risk and symptomatic patients

Nature Communications
Pancreatic ductal adenocarcinomas (PDAC) are among the most fatal cancers, in part due to frequent detection at advanced stages. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), the most sensitive diagnostic method of PDAC in current ...
Travis W. Moore, Elias Spiliotopoulos, Rowan L. Callahan, C. Ward Kirschbaum, Conner F. Bailey, Hyun Ji Kim, Breeshey Roskams-Hieter, Florian Goncalves, Dove Keith, Aaron J. Grossberg, Paul T. Spellman, Gordon B. Mills, Rosalie C. Sears, Terry K. Morgan, Thuy T. M. Ngo   +14 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The combined effect of socioeconomic status and metabolic syndrome on depression: the Korean National Health and Nutrition Examination Survey (KNHANES)

BMC Public Health, 2020
Background Depression shows different patterns depending on socioeconomic status (SES) and metabolic syndrome (MS). However, the nature of this association remains poorly understood.
B. Kim, E. Y. Park
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Identification and characterization of intact glycopeptides in human urine

Scientific Reports
Glycoproteins in urine have the potential to provide a rich class of informative molecules for studying human health and disease. Despite this promise, the urine glycoproteome has been largely uncharacterized.
Fernando Garcia-Marques, Keely Fuller, Abel Bermudez, Nikhiya Shamsher, Hongjuan Zhao, James D. Brooks, Mark R. Flory, Sharon J. Pitteri   +7 more
doaj   +1 more source

Can computed tomography predict nodal metastasis in breast cancer patients?

The Egyptian Journal of Radiology and Nuclear Medicine, 2022
Background Axillary lymph node metastasis is considered one of the main prognostic factors clinically used for the evaluation of breast cancer patient.
Sherihan Fakhry, Rasha Wessam Abdel Rahman, Hend Mahmoud Saied, Safaa Ibrahim Saif El-nasr   +3 more
doaj   +1 more source

Early detection of alkaptonuria

Indian Journal of Dermatology, Venereology and Leprology, 2005
Alkaptonuria is a rare disorder of metabolism characterized by deficiency of homogentisic acid oxidase. This leads to the characteristic features like darkening of urine, ochronosis and arthropathy. Darkening of urine is one of the first symptoms noticed by the parents of the child suffering from this disorder. Ochronosis is seen in various organs like
openaire   +2 more sources

Early Detection of Emphysema Progression [PDF]

, 2010
Emphysema is one of the most widespread diseases in subjects with smoking history. The gold standard method for estimating the severity of emphysema is a lung function test, such as forced expiratory volume in first second (FEV1). However, several clinical studies showed that chest CT scans offer more sensitive estimates of emphysema progression.
Vladlena Gorbunova, Sander S. A. M. Jacobs, Pechin Lo, Asger Dirksen, Mads Nielsen, Alireza Bab-Hadiashar, Marleen de Bruijne   +6 more
openaire   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source