Results 131 to 140 of about 5,988,743 (297)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Algal δ13C reveals climate changes during the Cambrian Explosion

Nature Communications
Carbon dioxide is a fundamental atmospheric component that regulates Earth’s climate. However, atmospheric CO2 levels (pCO2) during the Cambrian Explosion remain poorly constrained.
Chao Chang, Mingyu Zhao, Pengcheng Ju, Dongjing Fu, Ruiyun Li, Junfeng Guo, Kangjun Huang, Mingkun Wang, Linhao Cui, Yuning Yang, Mengyin Wu, Elena Yu. Golubkova, Dmitrii V. Grazhdankin, Robert R. Gaines, Xingliang Zhang   +14 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Finite-Difference Simulations of Time Reversed Acoustics in a Layered Earth Model [PDF]

, 2007
Traditionally an earthquake is located by using the arrival times of P and S phases. This uses only a limited portion of the information on a seismogram. A large part of the information carried by the waveform is not used.
Toksoz, M. Nafi, Lu, Rongrong
core  

Controls of Atmospheric Methane on Early Earth and Inhabited Earth-like Terrestrial Exoplanets

The Astrophysical Journal
Methane (CH _4 ) is a primarily biogenic greenhouse gas. As such, it represents an essential biosignature to search for life on exoplanets. Atmospheric CH _4 abundance on Earth-like inhabited exoplanets is likely controlled by marine biogenic production ...
Aika Akahori, Yasuto Watanabe, Eiichi Tajika   +2 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Oxidation of iron by giant impact and its implication on the formation of reduced atmosphere in the early Earth. [PDF]

Sci Adv, 2023
Choi J, Husband RJ, Hwang H, Kim T, Bang Y, Yun S, Lee J, Sim H, Kim S, Nam D, Chae B, Liermann HP, Lee Y.   +12 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source