Results 141 to 150 of about 9,813 (265)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Early Holocene Quantitative Summer Temperature Reconstructions in SE Lithuania Inferred from Chironomidae Data. [PDF]

Biology (Basel)
Gastevičienė N, Kluczynska G, Šeirienė V.   +2 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Bayesian analyses of radiocarbon dates suggest multiple origins of ceramic technology in Early Holocene Africa. [PDF]

Nat Commun
Rotunno R, Crema ER.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

On the ecological impact of prehistoric hunter-gatherers in Europe: Early Holocene (Mesolithic) and Last Interglacial (Neanderthal) foragers compared. [PDF]

PLoS One
Nikulina A, Zapolska A, Serge MA, Roche DM, Mazier F, Davoli M, Pearce EA, Svenning JC, van Wees D, Fyfe R, MacDonald K, Roebroeks W, Scherjon F.   +12 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Geoarchaeological research on site formation process, paleoenvironment, and human behaviors in the early Holocene of the Gobi Desert, Mongolia. [PDF]

PLoS One
Michalec G, Sikora R, Winiarska-Kabacińska M, Odsuren D, Wójcik A, Moska P, Szmit M, Bazargur D, Bobrowski P, Jórdeczka M, Szykulski J, Muntowski P, Gałaś A, Gunchinsuren B, Masojć M.   +14 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Global sea-level rise in the early Holocene revealed from North Sea peats. [PDF]

Nature
Hijma MP, Bradley SL, Cohen KM, van der Wal W, Barlow NLM, Blank B, Frechen M, Hennekam R, van Heteren S, Kiden P, Mavritsakis A, Meijninger BML, Reichart GJ, Reinhardt L, Rijsdijk KF, Vink A, Busschers FS.   +16 more
europepmc   +1 more source