Results 131 to 140 of about 1,850,573 (315)

Childcare providers’ attitudes, knowledge, and practice related to developmental monitoring to promote early identification and referral

, 2019
Although intervening early can improve child and family outcomes when a child has a developmental disability, most children with developmental delays are not identified prior to school entry.
Pizur-Barnekow, Kris, Chödrön, Gail, Barger, Brian, Puk-Ament, Alexandra, Viehweg, Stephan   +4 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Does the Early Bird Catch the Worm? Instrumental Variable Estimates of Educational Effects of Age of School Entry in Germany [PDF]

We estimate the effect of age of school entry on educational attainment using three different data sets for Germany, sampling pupils at the end of primary school, in the middle of secondary school and several years after secondary school.
Patrick A. Puhani, Andrea M. Weber
core   +2 more sources

Actions to prevent and identify fetal alcohol spectrum disorders to be implemented in general practice: a consensus

Frontiers in Medicine
IntroductionFetal alcohol exposure is the most common preventable cause of non-genetic intellectual disability. Fetal Alcohol Syndrome (FAS) is characterized by intellectual disability and distinctive facial features and affects 0.1% of live births ...
Sébastien Leruste, Sébastien Leruste, Alice Pouilley-Bax, Bérénice Doray, Bérénice Doray, Bérénice Doray, Bérénice Doray, Bérénice Doray, Bérénice Doray, Thierry Maillard, Frédérick Monin, Coralie Loubaresse, Catherine Marimoutou, Catherine Marimoutou, Michel Spodenkiewicz, Michel Spodenkiewicz, Michel Spodenkiewicz, Michel Spodenkiewicz   +17 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Robust Lessons about Practical Early Warning Systems [PDF]

Early warning systems (EWSs) are subject to restrictions that apply to exchange rates in general: fundamentals matter but their influence is small and unstable.
Menkhoff, Lukas, Beckmann, Daniela, Sawischlewski, Katja   +2 more
core  

Construction for a smart public health emergency management platform

Zhongguo gonggong weisheng
Public health emergency management is directly related to public health, social stability, and national security. Currently, public health emergency management in China faces challenges such as imperfect cross-departmental collaboration models, generally
Xing GAO, Qingkun CHEN, Panpan QIN, Yan WANG, Hongpu HU   +4 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Identification of lncRNAs involved in biological regulation in early age-related macular degeneration

, 2017
Wei Zhu,1,* Yi-Fang Meng,1,* Qian Xing,1 Jian-Jun Tao,1 Jiong Lu,1 Yan Wu2 1Department of Ophthalmology, Changshu No. 2 People’s Hospital, Changshu, China; 2Department of Ophthalmology, First Hospital Affiliated to Soochow University, Suzhou ...
Lu J, Meng YF, Zhu W, Xing Q, Tao JJ, Wu Y   +5 more
core  

Predictive validity of kindergarten screeners for young children with reading difficulties [PDF]

, 2002
Plan BResearch has long shown the importance of reading and the importance of early intervention to ensure all children have the opportunity to develop into competent readers.
Haats, Rikka Ann
core