Results 121 to 130 of about 1,850,573 (315)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

DEECD Early Childhood Intervention Reform Project [PDF]

, 2010
This literature review was commissioned by the Office for Children and Early Childhood Development, Department of Education and Early Childhood Development (DEECD), as part of its Early Childhood Intervention Services (ECIS) Reform Project (Stage 2 ...
June McLoughlin, John Forster, Anne Kennedy, Tim G. Moore, Susana Gavidia-Payne   +4 more
core  

Clinical impairment in premanifest and early Huntington's disease is associated with regionally specific atrophy.

, 2011
TRACK-HD is a multicentre longitudinal observational study investigating the use of clinical assessments and 3-Tesla magnetic resonance imaging as potential biomarkers for future therapeutic trials in Huntington's disease (HD).
Stout, J.C., Roos, Raymund AC, TRACK-HD investigators, Sarah J. Tabrizi, Langbehn, DR, David Craufurd, Langbehn, Douglas R, Callaghan, Jenny, Blair R. Leavitt, Alexandra Durr, Reilmann, R, Frajman, Ellen, Say, Miranda J, Henley, Susie M D, Johnson, H., Scahill, R.I., Roos, R.A.C., Rebecca Jones, Stephen L. Hicks, Craufurd, David, Keenan, Siobhan, Whitlock, Kathryn, Susie M.D. Henley, Fox, Nick, Queller, Sarah, Sturrock, Aaron, Say, M.J., Hobbs, N.Z., Milchman, Cassie, t'Hart, Ellen, Craufurd, D, Tabrizi, S.J., Bechtel, N., null null, Owen, Gail, Tabrizi, SJ, Leavitt, B.R., Miranda J. Say, Coleman, Allison, Henley, Susie MD, Jones, R., Jauffret, Céline, Hobbs, NZ, Landwehmeyer, Bernhard, Hyare, H., Jones, Rebecca, Wang, Chiachi, Natalie Bechtel, Dar Santos, Rachelle, Bechtel, N, Rosas, H Diana, Douglas R. Langbehn, Raymund A.C. Roos, Lehericy, S., Durr, A., Hoffman, Arndt, Bechtel, Natalie, Hicks, S.L., Christopher Kennard, Julie C. Stout, Stout, JC, Kennard, C, Henley, SM, Pepple, Tracey, Campbell, Colin, Langbehn, D.R., Jones, R, Rachael I. Scahill, Arran, Natalie, Reilmann, R., Harpreet Hyare, Lee, Stephanie, Henley, S.M.D., Durr, Alexandra, Ralf Reilmann, Campbell, Melissa, Mills, Jim, Axelson, Eric, Monaco, William, Hobbs, Nicola Z, Nicola Z. Hobbs, Bardinet, Eric, Say, MJ, Hicks, SL, Durr, A, Johnson, H, van Bogaard, Simon J A, Scahill, Rachael I, Lehéricy, S, Stout, Julie C, Leavitt, Blair R, Hyare, H, Valabre, Romain, Read, Joy, Ordidge, Roger, Hyare, Harpreet, Craufurd, D., Lehéricy, Stéphane, Decolongon, Joji, Stéphane Lehéricy, Roos, RA, Roos, Raymund A C, van der Grond, Jeroen, Kennard, C., Tabrizi, Sarah J, O'Regan, Alison, Scahill, RI, Marelli, Cecilia, Dumas, Eve, Lahiri, Nayana, Kennard, Christopher, Leavitt, BR, Hans Johnson, Reilmann, Ralf, Justo, Damian, Nigaud, Kevin, Johnson, Hans, Hicks, Stephen L   +117 more
core   +1 more source

Design and validation of a universal literacy screening tool for Catalan-speaking children

Frontiers in Education
This study describes the design, development, and piloting of a universal literacy screening tool for Catalan-speaking students (Grades 1–4) within a Multi-Tiered System of Support (MTSS) framework.
Clàudia Roca, Clàudia Roca, Marta Sanz, Cristina Cano, Víctor Vílchez, Aina Pujol, Cristina Benlloch, Sara Montore, Llorenç Andreu   +8 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Opening Conversations Improving the early identification of children and young people with SEND (Special Educational Needs and Disability) at risk of modern slavery in England

The report addresses the critical need for improved early identification and prevention of modern slavery risks among children and young people with Special Educational Needs and Disabilities (SEND) in England. The study highlights how children and young
Franklin, Anita, Bradley, Louise, Goff, Sarah, Greenaway, Jonathan   +3 more
core  

Gut microbiota and colorectal cancer: mechanistic insights, diagnostic advances, and microbiome-based therapeutic strategies

Frontiers in Microbiology
Colorectal cancer (CRC) is closely linked to gut microbiota dysbiosis. We synthesize evidence that carcinogenic microbes promote CRC through chronic inflammation, bacterial genotoxins, and metabolic imbalance, highlighting key pathways involving ...
Bingbing Bai, Bingbing Bai, Bingbing Bai, Bingbing Bai, Jianing Ma, Jianing Ma, Jianing Ma, Jianing Ma, Wenlong Xu, Wenlong Xu, Wenlong Xu, Wenlong Xu, Xiaomin Chen, Xiaomin Chen, Xiaomin Chen, Xiaomin Chen, Xu Chen, Xu Chen, Xu Chen, Xu Chen, Chao Lv, Chao Lv, Chao Lv, Chao Lv, Wei Su, Wei Su, Wei Su, Wei Su, Yaoxu Li, Yaoxu Li, Yaoxu Li, Yaoxu Li, Hongyin Sun, Hongyin Sun, Hongyin Sun, Hongyin Sun, Baoyin Zhang, Baoyin Zhang, Baoyin Zhang, Baoyin Zhang, Dejuan Xiang, Dejuan Xiang, Dejuan Xiang, Dejuan Xiang, Zhongsha Li, Zhongsha Li, Zhongsha Li, Zhongsha Li, Yuesong Wu, Yuesong Wu, Yuesong Wu, Yuesong Wu, Jian Sun, Jian Sun, Jian Sun, Jian Sun, Mingzhu Yin, Mingzhu Yin, Mingzhu Yin, Mingzhu Yin   +59 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source