Results 131 to 140 of about 1,560,476 (306)

Foundations for life: what works to support parent child interaction in the early years. [PDF]

, 2016
This report has assessed programmes available to UK commissioners, rather than considering programmes from around the world. This is the first time that EIF have used their own robust methods for rating the evidence and costs of early intervention ...
Chowdry, Haroon, Feinstein, Leon, Asmussen, Kirsten, Martin, Jack   +3 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

My risk perception; perspectives from youth at familial risk for bipolar disorder: a qualitative study

BMC Psychiatry
Background Offspring of parents with bipolar disorder (BD) are at increased risk of developing mental health difficulties. While research has documented elevated rates of psychiatric symptoms in this group, less is known about how young people themselves
Yusef Ahmed, Freja Pind Pilegaard, Stine Pedersen, Maj Vinberg, Christina Wagner   +4 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Reduction of DUP in early intervention programmes: No pain… almost no gain.

Considering the negative impact of long duration of untreated psychosis (DUP) on outcome, its reduction has become one of the aims of early intervention programmes.
Frischherz, M., Conus, P., Golay, P.
core   +1 more source

Acting early, changing lives: how prevention and early action saves money and improves wellbeing [PDF]

, 2013
Evidence indicates worsening or unacceptably high levels of problems amongst Australia’s children and young people. These problems will not improve – and could get worse – unless we are able to effectively intervene to prevent these problems from ...
Tim G. Moore, Tim Moore, Myfanwy McDonald   +2 more
core  

VEGFC/VEGFR3 Signaling‐Dependent Lymphatic Remodeling Modulates Cardiac Response to Pressure Overload

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiac lymphangiogenesis has been proposed as a potential therapeutic target to prevent the development of heart failure. However, the efficiency of systemically delivered VEGFC (vascular endothelial growth factor C) protein in inducing ...
Lina Su, Yuxia Cui, Manyan Wu, Shiran Yu, Chunying Zhang, Ziqi Song, Shuolei Li, Hang Lin, Zheng Lian, Chongyou Lee, Chuanfen Liu, Sufang Li, Junxian Song, Hong Chen   +13 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Implementation of the NDIS in the early childhood intervention sector in NSW: Final Report

, 2018
Early Childhood Intervention Australia (ECIA) NSW/ACT commissioned the Social Policy Research Centre to conduct research into the experiences of families and ECI service providers in the transition to the NDIS in New South Wales (NSW).
Fisher, K ; https://orcid.org/, Meltzer, A ; https://orcid.org/, Purcal, C ; https://orcid.org/, Boden, N, Hill, T ; https://orcid.org/   +4 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source