Results 111 to 120 of about 7,935,009 (305)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Enhancing child mental health: a stepped care approach by mental health professionals at an early intervention and rehabilitation centre for children, in India

Discover Psychology
As per the Global Burden of Disease survey, in India, developmental disabilities are projected to affect more than 11 million children in the age group of less than 5 years.
Vinyas Nisarga, Prerna Khar, Henal Shah
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Review of early childhood parenting, education and health intervention programs for Indigenous children and families in Australia [PDF]

, 2014
This paper provides a review of prevention and early intervention research literature that is focused on improving outcomes for Australian Indigenous children in the early childhood years. For the purposes of this paper, early childhood is defined as the
Jennifer Bowes, Rebekah Grace, Bowes, Jennifer, Grace, Rebekah (R19197)   +3 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The intermediate role of impulsive personality traits between attention‐deficit/hyperactivity disorder symptoms and suicidal ideation among patients with schizophrenia

PCN Reports
Aim While there is a general consensus on Attention‐Deficit/Hyperactivity Disorder (ADHD) serving as a possible suicide risk factor in a broad range of populations, scant research has been dedicated to addressing ADHD and suicidality in schizophrenia ...
Feten Fekih‐Romdhane, Jaweher Zaouali, Ameni Barketi, Farah Ghrissi, Majda Cheour, Souheil Hallit   +5 more
doaj   +1 more source

4-year outcome of a specialized early intervention treatment for adult onset psychosis (JCEP): A randomized controlled trial

, 2018
Despite advances in treatment of psychotic disorders, functional decline remains a prominent obstacle in the recovery pathway. Early intervention (EI) services worldwide have focused timely treatment on the first few years (i.e.
Chang, WC, Hui, CLM, Lee, HME, Chen, EYH, Chan, KW   +4 more
core   +1 more source

Deaf and Hard of Hearing Early Intervention: Perceptions of Family-Centered Practice

, 2020
This cross-sectional quantitative study investigated parents’ perceptions of the quality of family-centered practice in an early intervention service for young children who are deaf or hard of hearing through the use of the Measures of Processes of Care (
McKee, Jen, Stewart, Victoria, Slattery, Maddy   +2 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source