Results 51 to 60 of about 1,560,476 (306)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Critical period in early psychosis intervention: possible dose effect from longitudinal studies from Hong Kong

, 2016
Purpose: The critical period hypothesis – that the outcome of psychosis is largely determined within the first few years — constitutes a rationale for focusing psychosis intervention resources on the early years.
Chang, WC, Chan, KWS, Hui, CLM, Lee, HME, Chen, EYH   +4 more
core   +1 more source

Cognitive behavioural therapy for insomnia as an early intervention of mood disorders with comorbid insomnia: A randomized controlled trial

, 2023
ObjectiveTo evaluate the effectiveness of small-group nurse-administered cognitive behavioural therapy for insomnia (CBTI) as an early intervention of mood disorders with comorbid insomnia.MethodsA total of 200 patients with first-episode depressive or ...
Lau, Ying Yuet Esther, Kam, Ka‐Yee, Chung, Ka‐Fai, Yeung, Wing‐Fai, Lee, Che‐Kin, Lee, Chit‐Tat, Ho, Lai‐Ming, Ho, Yan‐Yee Fiona, Au, Chi‐Hung   +8 more
core   +1 more source

Ethical and existential perspectives : on the meaning of early Intervention

, 2014
Kapitlet bygger på erfarenheter från det projekt om tidig intervention för barn med funktionshinder i Ryssland och Vitryssland som författaren deltog i och som genomfördes 2004-2009.
Alwall, Jonas
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

SenseCam intervention based on cognitive ctimulation therapy framework for early-stage dementia. [PDF]

, 2011
Estimates suggest that Ireland will have 50,000 people with dementia by 2016 and over 100,000 by 2036. Combined with European total costs estimated in 2005 at €130 billion.
Piasek, Paulina, Smeaton, Alan F., Irving, Kate   +2 more
core  

Rapid-Cycle Evaluation in an Early Intervention Program for Children With Developmental Disabilities in South India: Optimizing Service Providers' Quality of Work-Life, Family Program Engagement, and School Enrollment

Frontiers in Public Health, 2020
Background: This paper explores how implementation and refinement of an early intervention (EI) program for children with delayed development was informed by an iterative, intentional and structured process of measurement.
Dinesh Krishna, Dinesh Krishna, Dinesh Krishna, Sankar Sahayraj Muthukaruppan, Aravind Bharathwaj, Ramasubramanian Ponnusamy, Bala Murugan Poomariappan, Sathiya Mariappan, Ayesha Beevi, Janna MacLachlan, Janna MacLachlan, Zoé Campbell, Chamila Anthonypillai, Marie Brien, Marie Brien, Cathy Cameron, Marina Flatman, Lesley Perlman, Stephanie Seilman, Stephanie Seilman, Abhinayaa Jeyapragash, Abhinayaa Jeyapragash, Lotte van der Haar, Joachim Krapels, Sankara Raman Srinivasan   +24 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source